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    题名: Cancer antigen-125 levels correlate with pleural effusions and COPD-related complications in people living at high altitude.
    作者: Li, Shengmei;Li, Shengmei;Ma, Huiying;Ma, Huiying;Gan, Lijun;Gan, Lijun;Ma, Xiuqing;Ma, Xiuqing;Wu, Shangjie;Wu, Shangjie;Li, Mangui;Li, Mangui;湯智昕;Chih-Hsin;Tang;Ts, Hsiao-Chi;Tsai, Hsiao-Chi
    贡献者: 生物科技學系
    日期: 2018-11
    上传时间: 2019-09-02 14:38:04 (UTC+8)
    摘要: Chronic obstructive pulmonary disease (COPD) is the most frequently encountered progressive lung disease in clinical practice. This study sought to determine the predictive ability of the tumor biomarker cancer antigen-125 (CA-125) in the identification of COPD in a cohort of 284 patients with COPD living at high altitude (with an average elevation of over 2500 m).

    Patients were classified by pleural effusion volumes into 4 categories and serum CA-125 concentrations were measured in each category. The analyses revealed that CA-125 concentrations were positively and significantly correlated with pleural effusion volume. CA-125 concentrations were also positively correlated with pulmonary heart disease and acute exacerbations of COPD, and negatively correlated with pulmonary hypertension.

    The study evidence suggests that serum CA-125 concentrations are positively correlated with the risk of pleural effusions among patients with COPD living in high-altitude areas, and that CA-125 concentrations are also correlated with pulmonary heart disease, acute exacerbations, and pulmonary hypertension.

    Keywords: cancer antigen125, chronic obstructive pulmonary disease, high altitude, pleural effusions
    显示于类别:[生物科技學系] 期刊論文


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