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    ASIA unversity > 醫學暨健康學院 > 心理學系 > 期刊論文 >  Item 310904400/111955


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111955


    Title: Pigment epithelium-derived factor inhibits lung cancer migration and invasion by upregulating exosomal thrombospondin 1
    Authors: Hu, Wen-Tsung;Huang, Wen-Tsung;Chon, Inn-Wen;Chong, Inn-Wen;Che, Hsiu-Lin;Chen, Hsiu-Lin;Li, Chia-Yang;Li, Chia-Yang;Chong-Chao, H;Hsieh, Chong-Chao;Kuo, Hsuan-Fu;Kuo, Hsuan-Fu;Ch, Chia-Yuan;Chang, Chia-Yuan;陳永祥;Chen, Yung-Hsian;Liu, Yu-Peng;Liu, Yu-Peng;Lu, Chi-Yu;Lu, Chi-Yu
    Contributors: 心理學系
    Date: 2018-12
    Issue Date: 2019-09-02 16:01:07 (UTC+8)
    Abstract: Exosomes are implicated in cancer cell development, migration and invasion. Pigment epithelium-derived factor (PEDF) is a secreted anticancer protein that can regulate lung cancer progression; however, the role of PEDF in non-small cell lung cancer (NSCLC), including metastasis and cancer cell-derived exosome secretion, is unclear. In this study, we analyzed the effects of PEDF on exosome-mediated migration, invasion, and tumorigenicity of cultured NSCLC cells. The results showed that PEDF overexpression significantly reduced NSCLC invasion and migration, while inducing cell aggregation, whereas PEDF knockdown had the opposite effects. Exosomes from NSCLC cells treated with recombinant PEDF had a significantly reduced ability to promote cancer cell motility, migration, and invasion compared to exosomes from untreated cells. Exosomes from PEDF-treated cells contained thrombospondin 1 (THBS1), which inhibited cytoskeletal remodeling and exosome-induced lung cancer cell motility, migration, and invasion. Furthermore, PEDF-overexpressing NSCLC cells formed smaller xenograft tumors with higher THBS1 expression compared to control tumors. Our findings indicate that PEDF decreases the metastatic potential of NSCLC cells through regulation of THBS1 release in cancer cell-derived exosomes, thus uncovering a new mechanism of lung cancer progression.
    Relation: CANCER LETTERS
    Appears in Collections:[心理學系] 期刊論文

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