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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111960

    Title: Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats
    Authors: Che, Wei?Kung;Chen, Wei?Kung;Tsa, Ying?Lan;Tsai, Ying?Lan;徐布;Shibu, Marthandam Asokan;She, Chia?Yao;Shen, Chia?Yao;張李淑女;Lee, Shu-Nu Chang;Che, Ray?Jade;Chen, Ray?Jade;Yao, Chun?Hsu;Yao, Chun?Hsu;Ban, Bo;Ban, Bo;郭薇雯;Kuo, Wei?Wen;黃志揚;Huang;Chih-Yang
    Contributors: 生物科技學系
    Date: 2018-12
    Issue Date: 2019-09-10 13:19:26 (UTC+8)
    Abstract: Exercise is known to be beneficial in controlling aging associated disorders however, the consequence of long-term exercise on cardiac health among aging population is not much clear. In this study the protective effect of exercise on aging associated cardiac disorders was determined using a D-galactose-induced aging model. Eight weeks old Sprague Dawley rats were given intraperitoneal injection of 150 mL/kg D-galactose. Swimming exercise was provided in warm water for 60 min/day for five days per week. Hematoxylin and eosin staining of cardiac tissue sections revealed cardiomyocyte disarrangements in the aging rat hearts but long-term exercise training showed improvements in the cardiac histology. Exercise training also enhanced the expression levels of proteins such as SIRT1, PGC-1α and AMPKα1 that are associated with energy homeostasis and further suppressed aging associated inflammatory cytokines. Our results show that long-term exercise training potentially enhances SIRT1 associated anti-aging signaling and provide cardio-protection against aging.

    Keywords: senescence, longevity, inflammation, swimming
    Relation: Aging-US
    Appears in Collections:[生物科技學系] 期刊論文

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