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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111973

    Title: Association of Exposure to Fine-Particulate Air Pollution and Acidic Gases with Incidence of Nephrotic Syndrome.
    Authors: 林詩怡
    Lin, Shih-Yi
    Hsu, Wu-Huei
    Lin, Cheng-Li
    Lin, Cheng-Chieh
    Chih-Hsueh, L
    Lin, Chih-Hsueh
    Wang, I-Kuan
    Hsu, Chung-Y.
    Kao, Chia-Hung
    Contributors: 生物資訊與醫學工程學系
    Date: 2018-12
    Issue Date: 2019-09-10 13:38:01 (UTC+8)
    Abstract: Background: Air pollution has been associated with autoimmune diseases. Nephrotic syndrome is a clinical manifestation of immune-mediated glomerulopathy. However, the association between nephrotic syndrome and air pollution constituents remains unknown. We conducted this nationwide retrospective study to investigate the association between PM2.5 and nephrotic syndrome. Methods: We used the Longitudinal Health Insurance Database (LHID) and the Taiwan Air Quality-Monitoring Database (TAQMD). We combined and stratified the LHID and the TAQMD data by residential areas of insurants linked to nearby air quality-monitoring stations. Air pollutant concentrations were grouped into four levels based on quartile. Univariable and multivariable Cox proportional hazard regression models were applied. Findings: Relative to Q1-level SO2, subjects exposed to the Q4 level were associated with a 2.00-fold higher risk of nephrotic syndrome (adjusted HR = 2.00, 95% CI = 1.66–2.41). In NOx, relative to Q1 NOx concentrations, the adjusted HRs of nephrotic syndrome risk were 1.53 (95% CI = 1.23–1.91), 1.30 (95% CI = 1.03–1.65), and 2.08 (95% CI = 1.69–2.56) for Q2, Q3, and Q4 levels, respectively. The results revealed an increasing trend for nephrotic syndrome risk correlating with increasing levels of NO, NO2, and PM2.5 concentrations. Interpretation: High concentrations of PM2.5, NO, NO2, and SO2 are associated with increased risk of nephrotic syndrome.

    Keywords: air pollution, PM2.5, nephrotic syndrome, retrospective study
    Relation: International Journal of Environmental Research and Public Health
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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