English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90587/105803 (86%)
Visitors : 16430467      Online Users : 351
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    ASIA unversity > 護理學院 > 護理學系 > 期刊論文 >  Item 310904400/111991


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111991


    Title: Clinical significance of glutamate metabotropic receptors in renal cell carcinoma risk and survival
    Authors: CY, Huang;CY, Huang;YM, Hsueh;YM, Hsueh;LC, Chen;LC, Chen;WC, Cheng;WC, Cheng;CC, Yu;CC, Yu;WJ, Chen;WJ, Chen;TL, Lu;TL, Lu;KJ, Lan;KJ, Lan;CH, Lee;CH, Lee;SP, Huang;SP, Huang;鮑柏穎;Bao, Bo-Ying
    Contributors: 護理學系
    Date: 2018-12
    Issue Date: 2019-09-10 14:02:32 (UTC+8)
    Abstract: Accumulating evidence suggests the roles of glutamate metabotropic receptors (GRMs) in cancer, in addition to synaptic signalling. The present study assessed the associations of genetic variants in eight GRM genes with regard to risk and overall survival (OS) in 780 renal cell carcinoma (RCC) patients and controls. After adjustment for known risk factors, GRM5 rs7102764 T was associated with an increased risk of RCC (P = 0.006). Additional analysis has provided evidence that rs7102764 T was correlated with a higher expression of GRM5, which is consistently found to be upregulated in tumours, compared to normal tissues. Furthermore, the GRM3 rs701332 C, GRM4 rs2499707 T, and GRM4 rs4713742 T alleles were significantly associated with a poorer OS (P ≤ 0.030). The three loci were also observed to have strong cumulative effects on OS. Additional analysis has revealed a significant genotype-expression correlation of rs2499707 T with increased GRM4 expression, which in turn leads to poorer OS in patients with RCC. GRMs might be involved in RCC development and progression, and genetic variants in GRMs might be promising biomarkers.
    Relation: Cancer Medicine
    Appears in Collections:[護理學系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML178View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback