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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112012


    Title: Resistin facilitates VEGF-A-dependent angiogenesis by inhibiting miR-16-5p in human chondrosarcoma cells.
    Authors: Shiou-Sheng Chen;Chih-Hsin Tang;Meng-Ju Chie;Chun-Hao Tsai;Yi-Chin Fong;Yung-Chang Lu;Wei-Cheng Chen;Cheng-Ta Lai;Chuan-Yen Wei;Huai-Ching Tai;Wen-Yi Chou;Shih-Wei Wang
    Contributors: 生物科技學系
    Date: 2019-01
    Issue Date: 2019-09-10 14:41:14 (UTC+8)
    Abstract: Resistin is an adipokine that is associated with obesity, inflammation, and various cancers. Chondrosarcomas are primary malignant bone tumors that have a poor prognosis. VEGF-A is a critical angiogenic factor that is known to promote angiogenesis and metastasis in chondrosarcoma. It is unknown as to whether resistin affects human chondrosarcoma angiogenesis. In this study, we show how resistin promotes VEGF-A expression and subsequently induces angiogenesis of endothelial progenitor cells (EPCs). Resistin treatment activated the phosphatidylinositol-3-kinase (PI3K) and Akt signaling pathways, while PI3K and Akt inhibitors or siRNA diminished resistin-induced VEGF-A expression. In vitro and in vivo studies revealed the downregulation of micro RNA (miR)-16-5p in resistin-induced VEGF-A expression and EPCs angiogenesis. We also found a positive correlation between resistin and VEGF-A expression, and a negative correlation between resistin and VEGF-A with miR-16-5p in chondrosarcoma patients. These findings reveal that resistin facilitates VEGF-A expression and angiogenesis through the inhibition of miR-16-5p expression via PI3K/Akt signaling cascades. Resistin may be a promising target in chondrosarcoma angiogenesis.
    Relation: Cell Death & Disease
    Appears in Collections:[生物科技學系] 期刊論文

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