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    题名: Plumbagin suppresses endothelial progenitor cell-related angiogenesis in vitro and in vivo
    作者: Hsiang-Ping;Lee, Hsiang-Ping;陳?均;Wan, Shih-Wei;Wang, Shih-Wei;Fong, Yi-Chin;Fong, Yi-Chin;蔡長海;Tsai, Fuu-Jen;Tsai, Fuu-Jen;鍾景光;黃志揚;Huang;Chih-Yang;Yan, Jai-Sing;Yang, Jai-Sing;Hsu, Yuan-Man;Hsu, Yuan-Man;湯智昕;Chih-Hsin;Tang
    贡献者: 生物科技學系
    日期: 2019-01
    上传时间: 2019-09-10 14:46:08 (UTC+8)
    摘要: Plumbagin, a naturally occurring naphthoquinone component isolated from the root of Plumbago zeylanica, reduces angiogenesis in human umbilical vein endothelial cells; whether plumbagin also has anti-angiogenic activity in human endothelial progenitor cells (EPCs) has remained unclear. Importantly, the recruitment of bone marrow-derived EPCs promotes physiological and pathological neovascularization. In this study, plumbagin inhibited vascular endothelial growth factor (VEGF)-induced migration and tube formation of human EPCs, without cytotoxic effects. We also found that plumbagin inhibited angiogenesis via the phospholipase C (PLC), Akt, extracellular-signal-regulated kinase (ERK), nuclear factor (NF)-κB and hypoxia-inducible factor (HIF)-1 signaling pathways. In an EPC Matrigel plug assay, plumbagin significantly diminished microvessel formation and EPC-specific marker expression. Our report is the first to reveal that plumbagin reduces EPC-related angiogenesis both in vitro and in vivo. Further evaluations of plumbagin are warranted, to determine its antitumor activity and other angiogenesis-related disorders.
    關聯: Journal of Functional Foods
    显示于类别:[生物科技學系] 期刊論文


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