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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112018

    Title: Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata
    Authors: Ch, Mei-Chuan;Chen, Mei-Chuan;汪貴珍;Wang;Guei-Jane;郭悅雄;Kuo, Yueh-Hsiung;Chian, Yin-Ru;Chiang, Yin-Ru;Cho, Ting-Yu;Cho, Ting-Yu;Ju, Yu-Ming;Ju, Yu-Ming;Tzong-Huei, L;Lee, Tzong-Huei
    Contributors: 生物科技學系
    Date: 2019-01
    Issue Date: 2019-09-10 14:49:33 (UTC+8)
    Abstract: Seven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with Emax values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1‒7 were not involved in the regulation of endothelial NOS-mediated NO production.
    Appears in Collections:[生物科技學系] 期刊論文

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