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    Title: A new triterpenoid and bioactive constituents from Eribotrya deflexa f. buisanensis
    Authors: Che, Jih-Jung;Chen, Jih-Jung;Wu, Ru-Fang;Wu, Ru-Fang;Hsia, Jen-Wen;Hsiao, Jen-Wen;Chen, Li-Chai;Chen, Li-Chai;Zhu, Tong-Fei;Zhu, Tong-Fei;郭悅雄;Kuo, Yueh-Hsiung;Su, Ping-Jyun;Sung, Ping-Jyun;Che, Ming-Jen;Cheng, Ming-Jen;Ch, Tzu-Cheng;Chang, Tzu-Cheng
    Contributors: 生物科技學系
    Date: 2019-01
    Issue Date: 2019-09-10 14:52:35 (UTC+8)
    Abstract: A new triterpenoid, methyl 2α-O-trans-feruloyl-3β-hydroxy-urs-12-en-28-oate (1), has been isolated from the leaves of Eriobotrya deflexa f. buisanensis, together with five known compounds, methyl ursolate (2), oleanolic acid (3), corosolic acid (4), 3-O-trans-caffeoyltormentic acid (5), and tormentic acid (6). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, oleanolic acid (3), corosolic acid (4), and tormentic acid (6) showed potent inhibition with IC50 values of 16.3 ± 1.8, 20.4 ± 2.2, and 18.3 ± 1.4 μM, respectively, against LPS-induced NO generation. In addition, 3-O-trans-caffeoyltormentic acid (5) exhibited anti-Dengue virus activity with IC50 value of 12.4 ± 1.1 μM against Dengue virus serotype 2 strain PL046.
    Appears in Collections:[Department of Biotechnology] Journal Article

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