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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112057


    Title: Arecoline-regulated ataxia telangiectasia mutated expression level in oral cancer progression
    Authors: Tu, Hsi-Feng;Tu, Hsi-Feng;Yuan, Michael;Chen, Michael Yuanchien;Chieh, Joseph;Lai, Joseph Chieh-Yui;Chen, Yi-Ling;Chen, Yi-Ling;Wong, Yih-Wen;Wong, Yih-Wen;Cheng-Chieh;Yang, Cheng-Chieh;Ch, Hsin-Yuan;Chen, Hsin-Yuan;Hsi, Shih-Min;Hsia, Shih-Min;石尹華;Shih, Yin-Hwa;Tzong-Ming, S;Shieh, Tzong-Ming
    Contributors: 健康產業管理學系
    Date: 2019-02
    Issue Date: 2019-09-18 10:56:05 (UTC+8)
    Abstract: Background
    Ataxia telangiectasia mutated (ATM) regulates DNA repair and cell cycle. The present study analyzed arecoline‐induced ATM expression during oral cancer progression.

    Methods
    In vitro studies were performed using oral squamous cell carcinoma (OSCC) cell lines treated with arecoline to analyze cell response and ATM regulation. in vivo studies were performed using immunohistochemistry to detect ATM expression in normal, oral potentially malignant disorder (OPMD), and OSCC tissues.

    Results
    Low‐dose arecoline induced cell proliferation, ATM promoter activity, and DNA repair. High‐dose arecoline induced cell cycle arrest, apoptosis, and DNA damage. ATM was overexpressed in OPMD tissues but was downregulated in OSCC tissues. ATM expression level was associated with the risk of developing dysplasia, buccal‐OSCC, and with OSCC survival rate.

    Conclusion
    High ATM expression helps DNA repair mechanisms to maintain the cells in the OPMD stage, but low ATM expression causes DNA damage accumulation to increase cell malignancy.
    Relation: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
    Appears in Collections:[健康產業管理學系] 期刊論文

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