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|Title: ||Arecoline-regulated ataxia telangiectasia mutated expression level in oral cancer progression|
|Authors: ||Tu, Hsi-Feng;Tu, Hsi-Feng;Yuan, Michael;Chen, Michael Yuanchien;Chieh, Joseph;Lai, Joseph Chieh-Yui;Chen, Yi-Ling;Chen, Yi-Ling;Wong, Yih-Wen;Wong, Yih-Wen;Cheng-Chieh;Yang, Cheng-Chieh;Ch, Hsin-Yuan;Chen, Hsin-Yuan;Hsi, Shih-Min;Hsia, Shih-Min;石尹華;Shih, Yin-Hwa;Tzong-Ming, S;Shieh, Tzong-Ming|
|Issue Date: ||2019-09-18 10:56:05 (UTC+8)|
Ataxia telangiectasia mutated (ATM) regulates DNA repair and cell cycle. The present study analyzed arecoline‐induced ATM expression during oral cancer progression.
In vitro studies were performed using oral squamous cell carcinoma (OSCC) cell lines treated with arecoline to analyze cell response and ATM regulation. in vivo studies were performed using immunohistochemistry to detect ATM expression in normal, oral potentially malignant disorder (OPMD), and OSCC tissues.
Low‐dose arecoline induced cell proliferation, ATM promoter activity, and DNA repair. High‐dose arecoline induced cell cycle arrest, apoptosis, and DNA damage. ATM was overexpressed in OPMD tissues but was downregulated in OSCC tissues. ATM expression level was associated with the risk of developing dysplasia, buccal‐OSCC, and with OSCC survival rate.
High ATM expression helps DNA repair mechanisms to maintain the cells in the OPMD stage, but low ATM expression causes DNA damage accumulation to increase cell malignancy.
|Relation: ||HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK|
|Appears in Collections:||[健康產業管理學系] 期刊論文|
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