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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112071

    Title: Electrospun Poly(γ–glutamic acid)/β–Tricalcium Phosphate Composite Fibrous Mats for Bone Regeneration
    Authors: 姚俊旭;Yao, Chun-Hsu;Yan, Shau-Pei;Yang, Shau-Pei;Yueh-Sheng, C;Chen, Yueh-Sheng;Chen, Kuo-Yu;Chen, Kuo-Yu
    Contributors: 生物資訊與醫學工程學系
    Date: 2019-02
    Issue Date: 2019-09-18 11:18:28 (UTC+8)
    Abstract: A poly(γ–glutamic acid)/β–tricalcium phosphate (γ–PGA/β–TCP) composite fibrous mat was fabricated using the electrospinning technique as a novel bone substitute. The mat was then cross-linked with cystamine in the presence of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide to improve its water-resistant ability. Scanning electron micrographs revealed that the γ–PGA/β–TCP fibers had a uniform morphology with diameters ranging from 0.64 ± 0.07 µm to 1.65 ± 0.16 µm. The average diameter of the fibers increased with increasing cross-linking time. Moreover, increasing the cross-linking time and decreasing the γ–PGA/β–TCP weight ratio decreased the swelling ratio and in vitro degradation rate of the composite fibrous mat. In vitro experiments with osteoblast-like MG-63 cells demonstrated that the mat with a γ–PGA/β–TCP weight ratio of 20 and cross-linked time of 24 h had a higher alkaline phosphatase activity and better cell adhesion. Furthermore, the rat cranial bone defect was created and treated with the γ–PGA/β–TCP composite fibrous mat to evaluate its potential in bone regeneration. After 8 weeks of implantation, micro computed tomography showed that the γ–PGA/β–TCP composite fibrous mat promoted new bone growth. These observations suggest that the γ–PGA/β–TCP composite fibrous mat has a potential application in bone tissue engineering.
    Relation: Polymers
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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