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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112092

    Title: Resistin Enhances Monocyte Chemoattractant Protein-1 Production in Human Synovial Fibroblasts and Facilitates Monocyte Migration.
    Authors: Ch, Wei-Cheng;Chen, Wei-Cheng;Wan, Shih-Wei;Wang, Shih-Wei;Li, Chih-Yang;Lin, Chih-Yang;Tsa, Chun-Hao;Tsai, Chun-Hao;Fong, Yi-Chin;Fong, Yi-Chin;Lin, Ting-Yi;Lin, Ting-Yi;We, Shun-Long;Weng, Shun-Long;Hua, Hsien-Da;Huang, Hsien-Da;Li, Kuang-Wen;Liao, Kuang-Wen;湯智昕;Chih-Hsin;Tang
    Contributors: 生物科技學系
    Date: 2019-03
    Issue Date: 2019-09-18 11:47:21 (UTC+8)
    Abstract: BACKGROUND/AIMS:
    The adipocyte-secreting adipokine, resistin, may play a critical role in the modulation of inflammatory diseases. Migration and infiltration of mononuclear cells into inflammatory sites are critical events during the development of osteoarthritis (OA). Monocyte chemoattractant protein-1 (MCP-1), also known as chemokine ligand 2 (CCL2), plays a critical role in the regulation of monocyte migration and infiltration. In this study, we show how resistin promotes MCP-1 expression in OA synovial fibroblasts and monocyte migration.

    We used qPCR to detect MCP-1 and miRNA expression. THP-1 migration was investigated by Transwell assay. The Western blotting was used to examine the resistinmediated signaling pathways.

    Resistin activated the phosphatidylinositol-3-kinase (PI3K), Akt and mammalian target of rapamycin (mTOR) signaling pathways, while PI3K, Akt and mTOR inhibitors or small interfering RNAs diminished resistin-induced MCP-1 expression and monocyte migration. We also demonstrate that resistin stimulates MCP-1mediated monocyte migration by suppressing microRNA (miR)-33a and miR-33b via the PI3K, Akt and mTOR signaling pathways.

    These results provide new insights into the mechanisms of resistin action that may have therapeutic implications for patients with OA.
    Appears in Collections:[生物科技學系] 期刊論文

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