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|Title: ||Contribution of Inflammatory Cytokine Interleukin-18 Genotypes to Renal Cell Carcinoma|
|Authors: ||Cha, Wen-Shin;Chang, Wen-Shin;Shen, Te-Chun;Shen, Te-Chun;Yeh, Wei-Lan;Yeh, Wei-Lan;Chien-Chih, Y;Yu, Chien-Chih;Lin, Hui-Yi;Lin, Hui-Yi;Wu, Hsi-Chin;Wu, Hsi-Chin;Tsa, Chia-Wen;Tsai, Chia-Wen;包大?;Bau, Da-Tian|
|Issue Date: ||2019-11-08 10:20:34 (UTC+8)|
|Abstract: ||Interleukin-18 (IL-18) is a multi-functional immuno-mediator in the development and progression of many types of infectious and inflammatory diseases. In this study, we evaluated the contribution of IL-18 genotypes to renal cell carcinoma (RCC) in Taiwan via the genotyping of IL-18 -656 (A/C), -607 (A/C), and -137 (G/C). Moreover, we analyzed their interactions with smoking, alcohol drinking, hypertension, and diabetes status. The results showed an association of the AC and CC genotypes of IL-18 −607 with a significant decrease in the risk of RCC compared with the AA genotype (odds ratio (OR) = 0.44 and 0.35, 95% confidence interval (CI) = 0.27–0.72 and 0.18–0.66, p = 0.0008 and 0.0010, respectively). Furthermore, a significantly lower frequency of the C allele at -607 was observed in the RCC group (35.3% vs. 49.8%; OR = 0.53; 95% CI = 0.35–0.71, p = 0.0003). However, IL-18 -656 and -137 did not exhibit a likewise differential distribution of these genotypes between the control and case groups. Stratifying the population according to smoking, alcohol drinking, hypertension, and diabetes status revealed a different distribution of IL-18 -607 genotypes among non-smokers, non-drinkers, and patients without diabetes, but not among smokers, drinkers, or patients with diabetes. These findings suggest that IL-18 -607 genotypes may play a role in the etiology and progression of RCC in Taiwan and may serve as a useful biomarker for early detection.
Keywords: genotype, IL-18, polymorphism, renal cell carcinoma, Taiwan
|Relation: ||INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES|
|Appears in Collections:||[生物資訊與醫學工程學系 ] 期刊論文|
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