English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90452/105769 (86%)
Visitors : 11966610      Online Users : 403
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112380


    Title: Effects of Chrysin on intestinal inflammation and gut microbiota in lipopolysaccharides-induced mice
    Authors: 吳文慈;Wu, Wen-Tzu;王智弘;Wang, Zhi-Hong
    Contributors: 食品營養與保健生技學系
    Date: 2019-04
    Issue Date: 2019-11-08 10:45:42 (UTC+8)
    Abstract: Chrysin is a natural flavonoid with a variety of biological activities such as antioxidant, antivirus, antitumor, antidiabetic and so on. However, the potential protective effects of chrysin, against lipopolysaccharides (LPS)-induced intestinal inflammation and its associated alteration of gut microbiota have not been studied. In the present study, male C57BL6/J mice were randomly divided into three groups and fed either normal chow diet (CON and LPS groups) or that supplemented with 1% (wt/wt) chrysin (CHY group) for 28 days followed by a single intraperitoneal injection of LPS (10 mg/kg BW). Control mice were given normal saline and all animals were kept for 72 hours before sacrifice. The results showed that chrysin attenuated histological injury of intestine and the production of pro-inflammatory cytokines, TNFα, IL-6 and IL-1β. When compared to the LPS group revealed at genus level, CHY increased the proportion of Alloprevotella and Lachnospiraceae NK4A136, and decreased Escherichia_Shigella and Akkermansia. Furthermore, LPS group showed lower species richness of gut microbiota compared to the control animals, and the reduction was reversed by the addition of chrysin. In conclusion, chrysin can attenuate the LPS-induced intestinal damage in mice. This protective effect appears to be mediated, in part, through beneficial changes to the microbiota.
    Relation: FASEB JOURNAL
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

    Files in This Item:

    There are no files associated with this item.



    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback