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    Title: Oral Submucous Fibrosis: A review on Etiopathogenesis;Diagnosis;and Therapy
    Authors: 石尹華;Shih, Yin-Hwa;Wa, Tong-Hong;Wang, Tong-Hong;Tzong-Ming, S;Shieh, Tzong-Ming;Tsen, Yu-Hsin;Tseng, Yu-Hsin
    Contributors: 健康產業管理學系
    Date: 2019-06
    Issue Date: 2019-11-15 10:38:17 (UTC+8)
    Abstract: Oral submucous fibrosis (OSF) is characterized by abnormal collagen deposition. It is a precancerous disorder and transforms into a malignant tumor in 1.5–15% of all cases. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. All of these greatly interfere with patient quality of life. The present review introduces OSF from a molecular perspective and summarizes what is known about its underlying mechanisms, diagnostic biomarkers, and therapeutic interventions. In addition to the aggressive treatment of OSF, its prevention is also important. Future research should, therefore, focus on improving the oral health literacy of the patients susceptible to OSF.

    Keywords: collagen deposition, diagnostic biomarkers, oral submucous fibrosis (OSF), precancerous disorder, therapeutic interventions, underlying mechanisms
    Appears in Collections:[Department of Healthcare Administration] Journal Article

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