ASIA unversity:Item 310904400/112518
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 90096/105238 (86%)
造访人次 : 7194989      在线人数 : 382
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/112518


    题名: Correlations between angiopoietin-2 gene polymorphisms and lung cancer progression in a Chinese Han population
    作者: Hu, Weiwei;Hu, Weiwei;湯智昕;Chih-Hsin;Tang;Che, Hsien-Te;Chen, Hsien-Te;Zhao, Jin;Zhao, Jin;Jin, Lulu;Jin, Lulu;Kang, Le;Kang, Le;Wu, Yueming;Wu, Yueming;Yin, Pengqing;Ying, Pengqing;Wan, Chao-Qun;Wang, Chao-Qun;Su, Chen-Ming;Su, Chen-Ming
    贡献者: 生物科技學系
    日期: 2019-06
    上传时间: 2019-11-15 10:49:07 (UTC+8)
    摘要: Lung cancer is the most common malignancy in China and is associated with a poor survival rate amongst Han Chinese. The high mortality is largely attributed to late-stage diagnosis, when treatment is largely ineffective. Identification of genetic variants could potentially assist with earlier diagnosis and thus more effective treatment. The development and progression of lung cancer is stimulated by angiopoietin-2 (Ang2), a ligand for Tie2, an endothelial tyrosine kinase. Patients with lung cancer with higher serum Ang2 levels have significantly poorer survival than patients with lower serum Ang2 levels. We explored the effects of Ang2 single nucleotide polymorphisms (SNPs) on lung cancer susceptibility. We used lung cancer tissue and serum samples to measure Ang2 expression in a Chinese Han population. Five Ang2 SNPs (rs2442598, rs734701, rs1823375, 11137037, and rs12674822) were analyzed using TaqMan SNP genotyping in 695 patients with lung cancer and 900 cancer-free controls. Carriers of the variant GT allele of rs12674822 had a higher risk of lung cancer than wild-type (GG) carriers, while the presence of the CC genotype at rs11137037 was associated with higher clinical stage disease compared with having the AA genotype. Our study is the first to document a correlation between Ang2 polymorphisms and lung cancer development and progression in people of Chinese Han ethnicity.
    關聯: Journal of Cancer
    显示于类别:[生物科技學系] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML18检视/开启


    在ASIAIR中所有的数据项都受到原著作权保护.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈