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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112527


    Title: Contribution of Caspase-8 Genotypes to Colorectal Cancer Risk in Taiwan
    Authors: Ming-Hsien, W;Wu, Ming-Hsien;Hung, Yi-Wen;Hung, Yi-Wen;Gong, Chi-Li;Gong, Chi-Li;Ch, Chi-Chang;Chao, Chi-Chang;Yue, Te-Cheng;Yueh, Te-Cheng;Shou-Cheng, W;Wang, Shou-Cheng;Lai, Yi-Liang;Lai, Yi-Liang;Hsu, Shih-Wei;Hsu, Shih-Wei;Fu, Chun-Kai;Fu, Chun-Kai;Wang, Yun-Chi;Wang, Yun-Chi;包大?;Bau, Da-Tian
    Contributors: 生物資訊與醫學工程學系
    Date: 2019-06
    Issue Date: 2019-11-15 10:59:06 (UTC+8)
    Abstract: BACKGROUND/AIM:
    The aim of this study was to examine the role of caspase-8 rs3834129 polymorphism on colorectal cancer (CRC) risk in Taiwanese CRC patients and healthy controls.

    MATERIALS AND METHODS:
    The caspase-8 rs3834129 (-652 6N insertion/deletion) polymorphic genotypes were analyzed in 362 patients with CRC and the same number of age- and gender-matched healthy subjects. The interaction of caspase-8 rs3834129 genotypes with personal behaviors and clinicopathological features were also examined.

    RESULTS:
    The percentage of variants ID and DD for caspase-8 rs3834129 genotype were 37.6 and 5.8% in CRC group and 39.0 and 6.6% in the control group, respectively (p for trend=0.7987). The allelic frequency distribution analysis showed that caspase-8 rs3834129 D allele conferred a non-significant lower susceptibility for CRC compared with I allele (OR=0.92, 95%CI=0.74-1.20, p=0.5063). There was no obvious link between caspase-8 rs3834129 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No statistically significant correlation was observed between caspase-8 rs3834129 genotypic distribution and age, gender, tumor size, location or metastasis status.

    CONCLUSION:
    Overall, caspase-8 rs3834129 genotypes may not serve as predictors for CRC risk or prognosis.

    Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

    KEYWORDS:
    Case–control study; Taiwan; caspase-8; colorectal cancer; genotype; polymorphism
    Relation: ANTICANCER RESEARCH
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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