English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90587/105803 (86%)
Visitors : 16430945      Online Users : 348
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112527

    Title: Contribution of Caspase-8 Genotypes to Colorectal Cancer Risk in Taiwan
    Authors: Ming-Hsien, W;Wu, Ming-Hsien;Hung, Yi-Wen;Hung, Yi-Wen;Gong, Chi-Li;Gong, Chi-Li;Ch, Chi-Chang;Chao, Chi-Chang;Yue, Te-Cheng;Yueh, Te-Cheng;Shou-Cheng, W;Wang, Shou-Cheng;Lai, Yi-Liang;Lai, Yi-Liang;Hsu, Shih-Wei;Hsu, Shih-Wei;Fu, Chun-Kai;Fu, Chun-Kai;Wang, Yun-Chi;Wang, Yun-Chi;包大?;Bau, Da-Tian
    Contributors: 生物資訊與醫學工程學系
    Date: 2019-06
    Issue Date: 2019-11-15 10:59:06 (UTC+8)
    Abstract: BACKGROUND/AIM:
    The aim of this study was to examine the role of caspase-8 rs3834129 polymorphism on colorectal cancer (CRC) risk in Taiwanese CRC patients and healthy controls.

    The caspase-8 rs3834129 (-652 6N insertion/deletion) polymorphic genotypes were analyzed in 362 patients with CRC and the same number of age- and gender-matched healthy subjects. The interaction of caspase-8 rs3834129 genotypes with personal behaviors and clinicopathological features were also examined.

    The percentage of variants ID and DD for caspase-8 rs3834129 genotype were 37.6 and 5.8% in CRC group and 39.0 and 6.6% in the control group, respectively (p for trend=0.7987). The allelic frequency distribution analysis showed that caspase-8 rs3834129 D allele conferred a non-significant lower susceptibility for CRC compared with I allele (OR=0.92, 95%CI=0.74-1.20, p=0.5063). There was no obvious link between caspase-8 rs3834129 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No statistically significant correlation was observed between caspase-8 rs3834129 genotypic distribution and age, gender, tumor size, location or metastasis status.

    Overall, caspase-8 rs3834129 genotypes may not serve as predictors for CRC risk or prognosis.

    Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

    Case–control study; Taiwan; caspase-8; colorectal cancer; genotype; polymorphism
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

    Files in This Item:

    There are no files associated with this item.

    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback