English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90451/105768 (86%)
Visitors : 11067248      Online Users : 578
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112565


    Title: Litchi (Litchi chinensis Sonn.) flower proanthocyanidin fraction exhibited protective efficacy to suppress nickel-induced expression for vascular endothelial growth factor in HepG2 cells
    Authors: 林昭田;Lin, Jau?Tien;張元衍;Chang, Yuan?Yen;陳億乘;Chen, Yi?Chen;廖伯霖;Liao, Po?Lin;楊登傑;Yang, Deng-Jye
    Contributors: 食品營養與保健生技學系
    Date: 2019-07
    Issue Date: 2019-11-22 10:15:56 (UTC+8)
    Abstract: The protective efficacy of litchi (Litchi chinensis Sonn.) flower proanthocyanidin fraction (LFPF) composed of (‐)‐epicatechin and proanthocyanidin A2 against vascular endothelial growth factor (VEGF) generation induced by nickel (Ni) in hepatocellular carcinoma (Hep G2) cells was studied. VEGF is an angiogenic inducer, which promotes tumor angiogenesis, leading to rapid tumor growth and metastasis. VEGF could be substantially induced in the Ni‐mediated Hep G2 cells. Through LFPF treatment, the Ni‐induced VEGF generation could be suppressed significantly. The inhibition of HIF‐1α expression by blocking phosphatidylinositol‐3‐kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways, and the suppression of Janus kinase 2 (JAK2)/signal transducers and activators of transcription 3 (STAT 3), and Raf‐1 proto‐oncogene, serine/threonine kinase (RAF1)/mitogen‐activated protein kinase (MEK1/2)/extracellular‐signal‐regulated kinase (ERK1/2) pathways are important molecular mechanisms for the LFPF action. LFPF should probably reduce the risk of liver cancer in Ni‐contaminated environments by inhibiting VEGF expression.
    Relation: JOURNAL OF BIOCHEMISTRY
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

    Files in This Item:

    There are no files associated with this item.



    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback