English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90453/105671 (86%)
Visitors : 15677514      Online Users : 155
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112709


    Title: Protective effect of autologous transplantation of resveratrol preconditioned adipose-derived stem cells in the treatment of diabetic liver dysfunction in rat model
    Authors: Tung?Sheng, C;Chen, Tung?Sheng;Ju, Da?Tong;Cecilia?Hsua;Day, Cecilia?Hsuan;Yeh, Yu?Lan;Yeh, Yu?Lan;Che, Ray?Jade;Chen, Ray?Jade;Padma, Vijaya;Viswanadha, Vijaya Padma;Cha, Ruey?Lin;Chang, Ruey?Lin;Yuan?Chuan, L;Lin, Yuan?Chuan;Yao, Chun?Hsu;Yao, Chun?Hsu;黃志揚;Huang, Chih-Yang
    Contributors: 醫學檢驗暨生物技術學系
    Keywords: diabetes;liver dysfunction;mesenchymal stem cells;resveratrol.
    Date: 2019-09
    Issue Date: 2020-08-20 15:12:33 (UTC+8)
    Publisher: 亞洲大學
    Abstract: Previous studies stated that stem cell functions are reduced under high glucose environment, leading to reduce stem cell capability of tissue regeneration. This study aimed to investigate if stem cells preconditioned with resveratrol show better therapeutic effect on the treatment of liver dysfunction in diabetic rats than stem cells without resveratrol precondition. Male Wistar rats were divided into four groups including sham, DM (diabetic rats), DM + ADSC (DM rats receiving autologous transplantation of adipose-derived stem cells), and DM + pre-R-ADSC (DM rats receiving ADSC preconditioned with resveratrol). Compared with sham group, experimental results showed that DM group induced suppression of survival, suppression of Sirt1, activation of apoptotic, and activation of fibrotic pathways, leading to liver dysfunction. Autologous transplantation of ADSC (DM + ADSC) improved above pathways except for fibrotic signaling. By contrast, transplantation of resveratrol preconditioned ADSC (DM + pre-R-ADSC) significantly improved above pathways including fibrosis. Supplemental evidences suggest that resveratrol precondition increases ADSC viability under high glucose stress via Sirt1 and IGF1R expressions. Furthermore, increased secretion of IGF1 via paracrine route also confirmed in ADSC preconditioned with resveratrol. The experimental results imply that ADSC preconditioned with resveratrol shows potential in the treatment of liver dysfunction in DM patients with liver dysfunction.
    Relation: Journal of Tissue Engineering and Regenerative Medicine
    Appears in Collections:[醫學檢驗暨生物技術學系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML56View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback