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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112791


    Title: Mechanisms of ischaemic neural progenitor proliferation: a regulatory role of the HIF-1α-CBX7 pathway
    Authors: 邱曉郁;李旭東;李國雄;趙昱;許重義;徐偉成
    Contributors: 職能治療學系
    Keywords: cell trafficking;cerebral ischaemia;hypoxia;hypoxia-inducible factor 1α (HIF-1α);neural progenitor cells (NPCs);polycomb repressor complex 1-chromobox7 (CBX7).
    Date: 2019-10
    Issue Date: 2020-08-28 15:03:28 (UTC+8)
    Publisher: 亞洲大學
    Abstract: Aims: Investigations of the molecular mechanisms of hypoxia- and ischaemia-induced endogenous neural progenitor cell (NPC) proliferation have mainly focused on factors secreted in response to environmental cues. However, little is known about the intrinsic regulatory machinery underlying the self-renewing division of NPCs in the brain after stroke.

    Methods and results: Polycomb repressor complex 1-chromobox7 (CBX7) has emerged as a key regulator in several cellular processes including stem cell self-renewal and cancer cell proliferation. The hypoxic environment triggering NPC self-renewal after CBX7 activation remains unknown. In this study, we found that the upregulation of CBX7 during hypoxia and ischaemia appeared to be from hypoxia-inducible factor-1α (HIF-1α) activation. During hypoxia, the HIF-1α-CBX7 cascade modulated NPC proliferation in vitro. NPC numbers significantly decreased in CBX7 knockout mice generated using CRISPR/Cas9 genome editing.

    Conclusions: We provided the novel insight that CBX7 expression is regulated through HIF-1α activation, which plays an intrinsically modulating role in NPC proliferation.
    Relation: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
    Appears in Collections:[職能治療學系] 期刊論文

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