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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112814

    Title: Effect of genipin crossliked chitosan scaffolds containing SDF-1 on wound healing in a rat model
    Authors: 姚俊旭;Yao, Chun-Hsu;Chen, Kuo-Yu;Chen, Kuo-Yu;Che, Mei-Huei;Cheng, Mei-Huei;陳悅生;Chen, Yueh-Sheng;Chiung-Hua, Hua H;Huang, Chiung-Hua
    Contributors: 生物資訊與醫學工程學系
    Date: 2019-10
    Issue Date: 2020-08-31 14:24:53 (UTC+8)
    Publisher: 亞洲大學
    Abstract: Prolonged healing is a severe problem for elderly and diabetic patients. Impaired angiogenesis, stem cell differentiation, and migration have been shown to delay wound healing. The chemokine stromal cell-derived factor-1 (SDF-1) plays an essential role in recruiting cells to wound sites and is suggested to be a candidate for tissue engineering. In this study, chitosan (CHI) scaffolds were crosslinked with nontoxic genipin (Gp) and further heparinized for SDF-1 immobilization. Then, the structures were evaluated for their physicochemical properties (porosity, swelling ratio, and water vapor transmission rate (WVTR)). The interaction between SDF-1 and heparin could sustain SDF-1 release, which has been shown to enhance human umbilical vein endothelial cell (HUVEC) 2D/3D migration. The investigation of the wound-healing activity of the SDF-1-loaded CHI scaffolds revealed a better wound recovery rate in vivo in healthy and streptozotocin-induced diabetic Sprague-Dawley (SD) rats. The histological analysis illustrated that the local of SDF-1 treatment scaffold at the wound site enhanced neovascularization. The wounds treated with SDF-1 scaffolds also exhibited higher vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-β) expression in Western blot assays. Based on the wound-healing activity and beneficial characteristics, the SDF-1-loaded CHI scaffold demonstrates potential as a material for treating skin wounds.
    Relation: Materials Science & Engineering C-Materials for Biological Applications
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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