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    Title: Ginsenoside Rg1 supplementation clears senescence-associated b-galactosidase in exercising human skeletal muscle
    Authors: Wu, Jinfu;Wu, Jinfu;Saov, Suchada;Saovieng, Suchada;Che, I-Shiung;Cheng, I-Shiung;Liu, Tiemin;Liu, Tiemin;Hon, Shangyu;Hong, Shangyu;Lin, Chang-Yu;Lin, Chang-Yu;Su, I-Chen;Su, I-Chen;黃志揚;Huang, Chih-Yang;Kuo, Chia-Hua;Kuo, Chia-Hua
    Contributors: 醫學檢驗暨生物技術學系
    Keywords: Cellular senescence;Endurance;Ergogenic aid;Inflammation;Macrophage
    Date: 2019-11
    Issue Date: 2020-08-31 15:45:45 (UTC+8)
    Publisher: 亞洲大學
    Abstract: Background: Ginsenoside Rg1 has been shown to clear senescence-associated beta-galactosidase (SA-bgal) in cultured cells. It remains unknown whether Rg1 can influence SA-b-gal in exercising human
    skeletal muscle.
    Methods: To examine SA-b-gal change, 12 young men (age 21  0.2 years) were enrolled in a randomized
    double-blind placebo controlled crossover study, under two occasions: placebo (PLA) and Rg1 (5 mg)
    supplementations 1 h prior to a high-intensity cycling (70% VO2max). Muscle samples were collected by
    multiple biopsies before and after cycling exercise (0 h and 3 h). To avoid potential effect of muscle
    biopsy on performance assessment, cycling time to exhaustion test (80% VO2max) was conducted on
    another 12 participants (age 23  0.5 years) with the same experimental design.
    Results: No changes of SA-b-gal were observed after cycling in the PLA trial. On the contrary, nine of the 12
    participants showed complete elimination of SA-b-gal in exercised muscle after cycling in the Rg1 trial
    (p < 0.05). Increases in apoptotic DNA fragmentation (PLA: þ87% vs. Rg1: þ133%, p < 0.05) and CD68þ
    (PLA:þ78% vs. Rg1:þ121%, p ¼ 0.17) occurred immediately after cycling in both trials. During the 3-h recovery,
    reverses in apoptotic nuclei content (PLA:þ5% vs. Rg1:32%, p < 0.01) and increases in inducible nitrate oxide
    synthase and interleukin 6 mRNA levels of exercised muscle were observed only in the Rg1 trial (p < 0.01).
    Conclusion: Rg1 supplementation effectively eliminates senescent cells in exercising human skeletal
    muscle and improves high-intensity endurance performance.
    Relation: Journal of Ginseng Research
    Appears in Collections:[Department of Medical Laboratory Science and Biotechnology] Journal Article

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