ASIA unversity:Item 310904400/112844
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 90453/105671 (86%)
造访人次 : 16042698      在线人数 : 100
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    题名: Ginsenoside Rg1 supplementation clears senescence-associated b-galactosidase in exercising human skeletal muscle
    作者: Wu, Jinfu;Wu, Jinfu;Saov, Suchada;Saovieng, Suchada;Che, I-Shiung;Cheng, I-Shiung;Liu, Tiemin;Liu, Tiemin;Hon, Shangyu;Hong, Shangyu;Lin, Chang-Yu;Lin, Chang-Yu;Su, I-Chen;Su, I-Chen;黃志揚;Huang, Chih-Yang;Kuo, Chia-Hua;Kuo, Chia-Hua
    贡献者: 醫學檢驗暨生物技術學系
    关键词: Cellular senescence;Endurance;Ergogenic aid;Inflammation;Macrophage
    日期: 2019-11
    上传时间: 2020-08-31 15:45:45 (UTC+8)
    出版者: 亞洲大學
    摘要: Background: Ginsenoside Rg1 has been shown to clear senescence-associated beta-galactosidase (SA-bgal) in cultured cells. It remains unknown whether Rg1 can influence SA-b-gal in exercising human
    skeletal muscle.
    Methods: To examine SA-b-gal change, 12 young men (age 21  0.2 years) were enrolled in a randomized
    double-blind placebo controlled crossover study, under two occasions: placebo (PLA) and Rg1 (5 mg)
    supplementations 1 h prior to a high-intensity cycling (70% VO2max). Muscle samples were collected by
    multiple biopsies before and after cycling exercise (0 h and 3 h). To avoid potential effect of muscle
    biopsy on performance assessment, cycling time to exhaustion test (80% VO2max) was conducted on
    another 12 participants (age 23  0.5 years) with the same experimental design.
    Results: No changes of SA-b-gal were observed after cycling in the PLA trial. On the contrary, nine of the 12
    participants showed complete elimination of SA-b-gal in exercised muscle after cycling in the Rg1 trial
    (p < 0.05). Increases in apoptotic DNA fragmentation (PLA: þ87% vs. Rg1: þ133%, p < 0.05) and CD68þ
    (PLA:þ78% vs. Rg1:þ121%, p ¼ 0.17) occurred immediately after cycling in both trials. During the 3-h recovery,
    reverses in apoptotic nuclei content (PLA:þ5% vs. Rg1:32%, p < 0.01) and increases in inducible nitrate oxide
    synthase and interleukin 6 mRNA levels of exercised muscle were observed only in the Rg1 trial (p < 0.01).
    Conclusion: Rg1 supplementation effectively eliminates senescent cells in exercising human skeletal
    muscle and improves high-intensity endurance performance.
    關聯: Journal of Ginseng Research
    显示于类别:[醫學檢驗暨生物技術學系] 期刊論文


    档案 描述 大小格式浏览次数


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈