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    ASIA unversity > 護理學院 > 護理學系 > 期刊論文 >  Item 310904400/112853

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112853

    Title: Level and Value of T Cell-derived Circulating Microparticles in Liver Cirrhosis Patients.
    Authors: 陳志弘;Chen, Chih-Hung;張家駱;Chang, Chia-Lo;陳冠宏;Che, Kuan-Hung;鄭本忠;Cheng, Ben-Chung;陳鴻華;Chen, Hong-Hwa;蔣依吾;Chiang, John Y;宋沛勳;Sung, Pei-Hsun;葉漢根;Yip, Hon-Kan
    Contributors: 護理學系
    Keywords: Circulating T-cell derived microparticles;inflammation;liver cirrhosis.
    Date: 2019-11
    Issue Date: 2020-09-01 14:10:18 (UTC+8)
    Publisher: 亞洲大學
    Abstract: Background/aim: We examined the hypothesis that T cell-derived-circulating microparticles (MPs) are increased in liver-cirrhosis (LC) patients compared to normal subjects and are also increased in chronic hepatitis compared to acute-decompensated-liver cirrhosis (ADLC).

    Patients and methods: A total of 66 LC patients, including 35 with ADLC and 31 with non-decompensated-LC (NDLC), were enrolled in the study. Ten volunteers served as controls.

    Results: Flow-cytometric analysis showed that circulating levels of T-cell derived MPs (i.e., total MPs and CD4+/CD8+/CD54+MPs) were higher in LC patients than in the controls (all p<0.003). Total MPs and CD8+MPs were higher in NDLC than in ADLC patients. There were good correlations between CD8+MPs and ADLC as well as between total MPs and chronic hepatitis. Multivariate-linear-regression analysis showed that NDLC was independently predictive of increased circulating CD8+MPs levels (p<0.05) and chronic hepatitis independently predictive of increased circulating total MPs levels (p<0.001)/CD4+MPs (p<0.05).

    Conclusion: Circulating levels of T-cell-derived MPs were increased in ADLC patients and were even more elevated in NDLC patients compared to healthy-control subjects.
    Relation: IN VIVO
    Appears in Collections:[護理學系] 期刊論文

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