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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112875


    Title: WISP-1 Promotes Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Cells Via the miR-153-3p/Snail Axis.
    Authors: Chan, An-Chen;Chang, An-Chen;Lien, Ming-Yu;Lien, Ming-Yu;Ts, Ming-Hsui;Tsai, Ming-Hsui;Hu, Chun-Hung;Hua, Chun-Hung;湯智昕;Chih-Hsin, Tang
    Contributors: 醫學檢驗暨生物技術學系
    Keywords: EMT;OSCC;Snail;WISP-1;miR-153-3p.
    Date: 2019-11
    Issue Date: 2020-09-01 14:49:37 (UTC+8)
    Publisher: 亞洲大學
    Abstract: Around half of all patients with oral squamous cell carcinoma (OSCC) present with lymphatic metastasis, a strong predictor of poor survival. Improving survival rates depends on preventing the first step in the "invasion-metastasis cascade," epithelial-to-mesenchymal transition (EMT), and developing antilymphangiogenesis therapies that antagonize lymphatic metastasis. The extracellular matrix-related protein WISP-1 (WNT1-inducible signaling pathway protein-1) stimulates bone remodeling and tumor progression. We have previously reported that WISP-1 promotes OSCC cell migration and lymphangiogenesis induced by vascular endothelial growth factor C (VEGF-C). This investigation sought to determine the role of WISP-1 in regulating EMT in OSCC. Our analysis of oral cancer data from The Cancer Genome Atlas (TCGA) database revealed significant and positive associations between levels of WISP-1 expression and clinical disease stage, as well as regional lymph node metastasis. We also found higher levels of WISP-1 expression in serum samples obtained from patients with OSCC compared with samples from healthy controls. In a series of in vitro investigations, WISP-1 activated EMT signaling via the FAK/ILK/Akt and Snail signaling transduction pathways and downregulated miR-153-3p expression in OSCC cells. Our findings detail how WISP-1 promotes EMT via the miR-153-3p/Snail axis in OSCC cells.
    Relation: Cancers
    Appears in Collections:[醫學檢驗暨生物技術學系] 期刊論文

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