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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112886


    Title: Oridonin, a natural diterpenoid, protected NGF-differentiated PC12 cells against MPP+- and kainic acid-induced injury
    Authors: Lin, Kuan-Ho;Lin, Kuan-Ho;Li, Chien-Yu;Li, Chien-Yu;Hsu, Yuan-Man;Hsu, Yuan-Man;Ts, Chang-Hai;Tsai, Chang-Hai;Tsai, Fuu-Jen;Tsai, Fuu-Jen;Ta, Chih-Hsin;Tang, Chih-Hsin;Yan, Jai-Sing;Yang, Jai-Sing;王智弘;Wang, Zhi-Hong;殷湄晶;Yin, Mei-chin
    Contributors: 食品營養與保健生技學系
    Keywords: NGF-differentiated PC12 cells;Oridonin;Parkinson's disease;Seizure.
    Date: 2019-11
    Issue Date: 2020-09-01 15:15:06 (UTC+8)
    Publisher: 亞洲大學
    Abstract: Oridonin (ORI) is a natural diterpenoid presented in some medicinal plants. The effects of pre-treatments from ORI against MPP+- or kainic acid (KA)-induced damage in nerve growth factor (NGF)-differentiated PC12 cells were investigated. Results showed that pre-treatments of ORI at 0.25-2 μM enhanced the viability and plasma membrane integrity of NGF-differentiated PC12 cells. MPP+ or KA exposure down-regulated Bcl-2 mRNA expression, up-regulated Bax mRNA expression, increased caspase-3 activity and decreased Na+-K+ ATPase activity. ORI pre-treatments at test concentrations reversed these changes. ORI pre-treatments decreased reactive oxygen species production, raised glutathione level, and increased glutathione peroxidase, glutathione reductase and catalase activities in MPP+ or KA treated cells. ORI pre-treatments lowered tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and prostaglandin E2 levels in MPP+ or KA treated cells. ORI also diminished MPP+ or KA induced increase in nuclear factor-κB binding activity. MPP+ exposure suppressed tyrosine hydroxylase (TH) mRNA expression and decreased dopamine content. KA exposure reduced glutamine synthetase (GS) mRNA expression, raised glutamate level and lowered glutamine level. ORI pre-treatments at 0.5-2 μM up-regulated mRNA expression of TH and GS, restored DA and glutamine content. These findings suggested that oridonin was a potent neuro-protective agent against Parkinson's disease and seizure.
    Relation: FOOD AND CHEMICAL TOXICOLOGY
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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