ASIA unversity:Item 310904400/112917
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 90453/105671 (86%)
造访人次 : 16042579      在线人数 : 87
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻
    ASIA unversity > 護理學院 > 護理學系 > 期刊論文 >  Item 310904400/112917


    题名: Prognostic Value of CD1B in Localised Prostate Cancer
    作者: CH, Lee;CH, Lee;LC, Chen;LC, Chen;CC, Yu;CC, Yu;WH, Lin;WH, Lin;VC, Lin;VC, Lin;CY, Huang;CY, Huang;TL, Lu;TL, Lu;SP, Huang;SP, Huang;鮑柏穎;Bao, Bo-Ying
    贡献者: 護理學系
    关键词: CD antigen;CD1B;biomarker;prognosis;prostate cancer
    日期: 2019-11
    上传时间: 2020-09-03 15:27:13 (UTC+8)
    出版者: 亞洲大學
    摘要: Cluster of differentiation (CD) antigens are cell surface markers used to differentiate haematopoietic cell types. These antigens are present in various malignancies and are reportedly linked to patient prognosis; however, they have not been implemented as prostate cancer progression markers. Here, we aimed to assess the impact of genetic variation in haematopoietic cell CD markers on clinical outcomes in patients with prostate cancer. An association study of 458 patients with prostate cancer was conducted to identify single-nucleotide polymorphisms in 11 candidate CD marker genes associated with biochemical recurrence (BCR) after radical prostatectomy. Identified predictors were further evaluated in an additional cohort of 185 patients. Joint population analyses showed that CD1B rs3181082 is associated with BCR (adjusted hazard ratio 1.42, 95% confidence interval 1.09-1.85, p = 0.010). In addition, rs3181082 overlapped with predicted transcriptional regulatory elements and affected CD1B expression. Furthermore, low CD1B expression correlated with poorer BCR-free survival. Our results indicated that CD1B rs3181082 confers prostate cancer progression and may help improve clinical prognostic stratification.
    關聯: International Journal of Environmental Research and Public Health
    显示于类别:[護理學系] 期刊論文


    档案 描述 大小格式浏览次数


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈