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    ASIA unversity > 護理學院 > 護理學系 > 期刊論文 >  Item 310904400/112918


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112918


    Title: Mechanistic Insight of Cyclin-Dependent Kinase 5 in Modulating Lung Cancer Growth
    Authors: Shazza, G. M.;Prince, G. M. Shazzad Hossain;陳美智;Chen, Mei-chih
    Contributors: 護理學系
    Keywords: CDK5;cytoskeletal remodeling;DNA damage;lung cancer;PD-L1;tumor suppressor
    Date: 2019-11
    Issue Date: 2020-09-03 15:31:40 (UTC+8)
    Publisher: 亞洲大學
    Abstract: Lung harbors the growth of primary and secondary tumors. Even though numerous factors regulate the complex signal transduction and cytoskeletal remodeling toward the progression of lung cancer, cyclin-dependent kinase 5 (Cdk5), a previously known kinase in the central nervous system, has raised much attention in the recent years. Patients with aberrant Cdk5 expression also lead to poor survival. Cdk5 has already been employed in various cellular processes which shape the fate of cancer. In lung cancer, Cdk5 mainly regulates tumor suppressor genes, carcinogenesis, cytoskeletal remodeling, and immune checkpoints. Inhibiting Cdk5 by using drugs, siRNA or CRISP-Cas9 system has rendered crucial therapeutic advantage in the combat against lung cancer. Thus, the relation of Cdk5 to lung cancer needs to be addressed in detail. In this review, we will discuss various cellular events modulated by Cdk5 and we will go further into their underlying mechanism in lung cancer.
    Relation: CHINESE JOURNAL OF PHYSIOLOGY
    Appears in Collections:[護理學系] 期刊論文

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