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    Title: The Role of N-methyl-D-aspartate Receptor on Late-Life Depression
    Authors: Hsi, Men-Ting;Hsieh, Men-Ting;藍先元;Lane, Hsien Yuan;Chieh-Hsin, L;Lin, Chieh-Hsin
    Contributors: 心理學系
    Keywords: N-methyl-D-aspartate receptor ; NMDA ; NMDAR ; late-life depression
    Date: 2019-12
    Issue Date: 2020-09-03 16:02:37 (UTC+8)
    Publisher: 亞洲大學
    Abstract: As the life expectancy of general population becomes longer, the prevalence of geriatric mental disorders increases rapidly. Late-life depression (LLD) is the secondly common mental disorders in the elders. LLD has negative impacts on patient's life and is also related to multiple physical diseases, mental problems, and dementia. Treating LLD is important, but there is a substantial proportion of patients with depression who do not show satisfactory therapeutic response or recovery with current antidepressant treatment. Thus, developing new medication is important. Recent studies showed that abnormal activation of N-methyl-D-aspartate receptor (NMDAR) would result in several neurological and psychiatric disorders, such as major depressive disorder, schizophrenia, Alzheimer's disease, and Parkinson diseases. Medication associated with NMDAR is considered to have great potential in treating depression. NMDAR could be activated by glutamate and in turn initiating signaling cascades which are involved in both neural connectivity and neural plasticity. Also, several animal studies suggest that aging alters the expression of NMDAR. The binding functions and intensities of NMDARs decline in aging animal models. Thus, medication involving with NMDARs might take important role in treating depression, especially in the elders. Current medication related with NMDARs includes nonselective NMDAR antagonists (such as ketamine), selective NMDAR antagonists, NMDA agonist and partial agonists, and glutamate release inhibitors. However, more clinical studies should be conducted to investigate the antidepressant effects of these medications.
    Relation: International Journal of Gerontology
    Appears in Collections:[Department of Psychology] Journal Article

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