ASIA unversity:Item 310904400/112936
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    题名: The Joint Effect of Interleukin-12B rs3212227 Genotype and Behavioral Factors on Oral Cancer Risk in Taiwanese
    作者: LI, CHING-HAO;LI, CHING-HAO;SUN, KUO-TING;SUN, KUO-TING;LI, XIN;LI, XIN;LIANG-CHUN, S;SHIH, LIANG-CHUN;CHE, LIANG-YU;CHEN, LIANG-YU;CHIEN-CHIH, Y;YU, CHIEN-CHIH;WANG, YUN-CHI;WANG, YUN-CHI;CHA, WEN-SHIN;CHANG, WEN-SHIN;TSA, CHIA-WEN;TSAI, CHIA-WEN;LI, CHI-YUAN;LI, CHI-YUAN;包大?;Bau, Da-Tian
    贡献者: 生物資訊與醫學工程學系
    关键词: Alcohol drinking;Taiwan;betel quid;genotype;interleukin-12B;oral cancer;polymorphism;smoking.
    日期: 2019-12
    上传时间: 2020-09-04 14:03:39 (UTC+8)
    出版者: 亞洲大學
    摘要: Background/aim: Oral cancer is of the highest incidence worldwide in Taiwan, and a better marker for personalized therapeutic strategies such as immunotherapies is urgently needed. Interleukin-12 (IL12) is a cytokine that has been reported to exhibit potent tumoricidal effects, however, its genotypic contribution to oral cancer is still largely unknown. The current study aimed at investigating whether IL12B rs3212227 genotype is associated with oral cancer in Taiwan.

    Materials and methods: Genotypic characteristics of IL12B rs3212227 were determined among 958 oral cancer cases and age- and gender-matched individuals via typical polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology.

    Results: The AA, AC and CC genotypes of IL12B rs3212227 were 38.2, 38.9 and 22.9% in the case group and 36.2, 41.5 and 22.3% in the control group (p=0.5189), respectively.

    Conclusion: IL12B rs3212227 genotype was associated with oral cancer risk only in betel quid chewers.
    關聯: ANTICANCER RESEARCH
    显示于类别:[生物資訊與醫學工程學系 ] 期刊論文

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