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|Title: ||Association of Matrix Metalloproteinase-9 rs3918242 Promoter Genotypes With Colorectal Cancer Risk|
|Authors: ||MING-HSIEN, W;WU, MING-HSIEN;TZEN, HUEY-EN;TZENG, HUEY-EN;WU, CHENG-NAN;WU, CHENG-NAN;YUE, TE-CHENG;YUEH, TE-CHENG;PEN, YEN-CHUN;PENG, YEN-CHUN;TSA, CHUN-HAO;TSAI, CHUN-HAO;WANG, YUN-CHI;WANG, YUN-CHI;KE, TAO-WEI;KE, TAO-WEI;PE, JEN-SHENG;PEI, JEN-SHENG;CHA, WEN-SHIN;CHANG, WEN-SHIN;包大?;Bau, Da-Tian|
|Keywords: ||Case-control study;MMP-9;Taiwan;colorectal cancer;genotype;polymorphism.|
|Issue Date: ||2020-09-04 14:05:02 (UTC+8)|
|Abstract: ||Background/aim: Matrix metalloproteinase-9 (MMP-9) is responsible for modifying extracellular components and plays a crucial role in the metastatic behavior of cancer. This study aimed at examining the role of MMP-9 rs3918242 genotypes on colorectal cancer (CRC) risk.
Materials and methods: A total of 362 CRC patients and 362 healthy subjects in Taiwan, were examined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology.
Results: The MMP-9 rs3918242 TT genotype carriers had a slightly increased risk of CRC compared to CC carriers (p=0.1642, OR=1.88, 95% CI=0.84-4.16). Patients of CT/TT genotypes were on significantly higher risk of metastasis (p=0.0027) than those of CC genotype. No obvious association was found between MMP-9 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No significant correlation was observed between MMP-9 genotypic distributions with age, gender, tumor size or location.
Conclusion: MMP-9 rs3918242 genotypes may interact with BMI to serve as a predictor for higher CRC risk, and independently as a predictor for metastasis.
|Relation: ||ANTICANCER RESEARCH|
|Appears in Collections:||[生物資訊與醫學工程學系 ] 期刊論文|
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