English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90451/105768 (86%)
Visitors : 11001243      Online Users : 607
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112937


    Title: Association of Matrix Metalloproteinase-9 rs3918242 Promoter Genotypes With Colorectal Cancer Risk
    Authors: MING-HSIEN, W;WU, MING-HSIEN;TZEN, HUEY-EN;TZENG, HUEY-EN;WU, CHENG-NAN;WU, CHENG-NAN;YUE, TE-CHENG;YUEH, TE-CHENG;PEN, YEN-CHUN;PENG, YEN-CHUN;TSA, CHUN-HAO;TSAI, CHUN-HAO;WANG, YUN-CHI;WANG, YUN-CHI;KE, TAO-WEI;KE, TAO-WEI;PE, JEN-SHENG;PEI, JEN-SHENG;CHA, WEN-SHIN;CHANG, WEN-SHIN;包大?;Bau, Da-Tian
    Contributors: 生物資訊與醫學工程學系
    Keywords: Case-control study;MMP-9;Taiwan;colorectal cancer;genotype;polymorphism.
    Date: 2019-12
    Issue Date: 2020-09-04 14:05:02 (UTC+8)
    Publisher: 亞洲大學
    Abstract: Background/aim: Matrix metalloproteinase-9 (MMP-9) is responsible for modifying extracellular components and plays a crucial role in the metastatic behavior of cancer. This study aimed at examining the role of MMP-9 rs3918242 genotypes on colorectal cancer (CRC) risk.

    Materials and methods: A total of 362 CRC patients and 362 healthy subjects in Taiwan, were examined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology.

    Results: The MMP-9 rs3918242 TT genotype carriers had a slightly increased risk of CRC compared to CC carriers (p=0.1642, OR=1.88, 95% CI=0.84-4.16). Patients of CT/TT genotypes were on significantly higher risk of metastasis (p=0.0027) than those of CC genotype. No obvious association was found between MMP-9 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No significant correlation was observed between MMP-9 genotypic distributions with age, gender, tumor size or location.

    Conclusion: MMP-9 rs3918242 genotypes may interact with BMI to serve as a predictor for higher CRC risk, and independently as a predictor for metastasis.
    Relation: ANTICANCER RESEARCH
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML5View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback