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    ASIA unversity > 護理學院 > 護理學系 > 期刊論文 >  Item 310904400/112946

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112946

    Title: Risk of Venous Thromboembolic Events in Patients with Osteonecrosis of the Femoral Head Undergoing Primary Hip Arthroplasty.
    Authors: 宋沛勳;Sung, Pei-Hsun;楊曜旭;Yang, Yao-Hsu;江心茹;Chiang, Hsin-Ju;蔣依吾;Chiang, John Y.;葉漢根;Yip, Hon-Kan;李炫昇;Lee, Mel S.
    Contributors: 護理學系
    Keywords: osteonecrosis of femoral head;hip replacement surgery;venous thromboembolic events;deep venous thrombosis;pulmonary embolism;risk;population-based cohort study
    Date: 2019-12
    Issue Date: 2020-09-04 14:34:38 (UTC+8)
    Publisher: 亞洲大學
    Abstract: Previous data have shown patients with osteonecrosis of the femoral head (ONFH) have increased lifelong risk of unprovoked venous thromboembolic events (VTE) as compared with the general population, according to sharing common pathological mechanism of endothelial dysfunction. However, whether the risk of VTE increases in those ONFH patients undergoing major hip replacement surgery remains unclear. This is a retrospective nationwide Asian population-based study. From 1997 to 2013, a total of 12,232 ONFH patients receiving partial or total hip replacement for the first time and revision surgeries were retrospectively selected from Taiwan Health Insurance surgical files. By 1:1 matching on age, sex, surgical types, and socioeconomic status, 12,232 subjects without ONFH undergoing similar hip surgery were selected as non-ONFH group. The incidence and risk of post-surgery VTE, including deep venous thrombosis (DVT) and pulmonary embolism (PE), were compared between the ONFH and non-ONFH groups. Results showed that 53.8% of ONFH patients were male and the median age was 61.9 years old. During the mean follow-up period of 6.4 years, the incidences of VTE (1.4% vs. 1.2%), DVT (1.1% vs. 0.9%), and PE (0.4% vs. 0.4%) were slightly but insignificantly higher in the ONFH than in the non-ONFH group undergoing the same types of major hip replacement surgery (all p-values > 0.250). Concordantly, we found no evidence that the risk of VTE was increased in the ONFH patients as compared with the non-ONFH counterparts (adjusted HR 1.14; 95% CI 0.91–1.42; p = 0.262). There were also no increased risks for DVT and PE in the ONFH subgroups stratified by comorbidities, drug exposure to pain-killer or steroid, and follow-up duration after surgery, either. In conclusion, hip arthroplasty in Asian patients with ONFH is associated with similar rates of VTE as compared to patients with non-ONFH diagnoses.
    Relation: Journal of Clinical Medicine
    Appears in Collections:[護理學系] 期刊論文

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