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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112990

    Title: The making of a flight feather: Bio-architectural principles and adaptation
    Authors: Cha, Wei-Ling;Chang, Wei-Ling;Wu, Hao;Wu, Hao;Chiu, Yu-Kun;Chiu, Yu-Kun;Wang, Shuo;Wang, Shuo;Jia, Ting-Xin;Jiang, Ting-Xin;Lu, Zhong-Lai;Luo, Zhong-Lai;Li, Yen-Cheng;Lin, Yen-Cheng;Li, Ang;Li, Ang;許瑞廷;Hsu, Jui-Ting;黃恆立;Huang, Heng Li
    Contributors: 生物資訊與醫學工程學系
    Keywords: evolution;development;stem cells;dermal papilla;keratin;composite biomaterials;morphogenesis;branching morphogenesis;amber;feathered dinosaurs
    Date: 2019-12
    Issue Date: 2020-09-07 13:38:46 (UTC+8)
    Publisher: 亞洲大學
    Abstract: The evolution of flight in feathered dinosaurs and early birds over millions of years required flight feathers whose architecture features hierarchical branches. While barb-based feather forms were investigated, feather shafts and vanes are understudied. Here, we take a multi-disciplinary approach to study their molecular control and bio-architectural organizations. In rachidial ridges, epidermal progenitors generate cortex and medullary keratinocytes, guided by Bmp and transforming growth factor β (TGF-β) signaling that convert rachides into adaptable bilayer composite beams. In barb ridges, epidermal progenitors generate cylindrical, plate-, or hooklet-shaped barbule cells that form fluffy branches or pennaceous vanes, mediated by asymmetric cell junction and keratin expression. Transcriptome analyses and functional studies show anterior-posterior Wnt2b signaling within the dermal papilla controls barbule cell fates with spatiotemporal collinearity. Quantitative bio-physical analyses of feathers from birds with different flight characteristics and feathers in Burmese amber reveal how multi-dimensional functionality can be achieved and may inspire future composite material designs.
    Relation: CELL
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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