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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/113035


    Title: The Association of MMP7 Genotype With Pterygium
    Authors: HU, PEI-SHIN
    HU, PEI-SHIN
    WANG, YUN-CHI
    WANG, YUN-CHI
    LI, CHENG-HSI
    LIAO, CHENG-HSI
    HSIA, NING-YI
    HSIA, NING-YI
    WU, MENG-FENG
    WU, MENG-FENG
    YAN, JAI-SING
    YANG, JAI-SING
    CHIEN-CHIH, Y
    YU, CHIEN-CHIH
    CHA, WEN-SHIN
    CHANG, WEN-SHIN
    PEI-SHIN HU;PEI-SHIN HU;YUN-CHI WANG;YUN-CHI WANG;CHENG-HSI LI;CHENG-HSI LIAO;NING-YI HSIA;NING-YI HSIA;MENG-FENG WU;MENG-FENG WU;JAI-SING YAN;JAI-SING YANG;CHIEN-CHIH Y;CHIEN-CHIH YU;WEN-SHIN CHA;WEN-SHIN CHANG;包大?;Da-Tian Bau;CHIA-WEN TSA;CHIA-WEN TSAI
    Bau, Da-Tian
    TSA, CHIA-WEN
    TSAI, CHIA-WEN
    Contributors: 資訊電機學院生物資訊與醫學工程學系
    Keywords: Age;gender;genotype;MMP7;polymorphism;pterygium Taiwan
    Date: 2020-01-20
    Issue Date: 2020-10-14 13:45:41 (UTC+8)
    Publisher: 亞洲大學
    Abstract: Background/Aim: In literature, few studies have examined the diagnostic or prognostic potential of matrix metalloproteinases (MMP) in pterygium, whose formation and progression are closely related to imbalance in the extracellular microenvironment. In this study, we investigated the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to pterygium risk. Materials and Methods: A total of 134 cases and 268 controls were collected and their MMP7 genotypes at A-181G and C-153T were examined by polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The AA, AG and GG genotypes at MMP7 promoter A-181G were non-significantly differentially distributed between the two groups at 85.8, 11.2 and 3.0%, respectively, in pterygium cases and 88.4, 9.7 and 1.9% in controls, respectively (p for trend=0.6822). There was no polymorphic genotype for MMP7 C-153T among our Taiwanese cohort. Conclusion: A-181G and C-153T genotypes at MMP7 do not have a direct role in determining Taiwanese susceptibility to pterygium.
    Relation: IN VIVO
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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