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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/113039


    Title: Fasting plasma glucose variability and HbA1c are associated with peripheral artery disease risk in type 2 diabetes
    Authors: Yan, Chun-Pai
    Yang, Chun-Pai
    Cheng-Chieh
    Lin, Cheng-Chieh
    Li, Chia-Ing
    Li, Chia-Ing
    Chiu-Shong, L
    Liu, Chiu-Shong
    Chih-Hsueh, L
    Lin, Chih-Hsueh
    Hwan, Kai-Lin
    Hwang, Kai-Lin
    Yan, Shing-Yu
    Yang, Shing-Yu
    李采娟
    Li, Tsai-Chung
    Contributors: 醫學暨健康學院健康產業管理學系
    Date: 2020-01-20
    Issue Date: 2020-10-14 13:51:35 (UTC+8)
    Abstract: Background
    This study investigated whether visit-to-visit fasting plasma glucose (FPG) variability, as measured by the coefficient of variation (CV), increased peripheral artery disease (PAD) risk.

    Methods
    Individuals with type 2 diabetes from the National Diabetes Care Management Program during the period 2002–2004, ≥ 30 years of age, and free of PAD (n = 30,932) were included and monitored until 2011. Cox proportional hazards regression models were implemented to analyze related determinants of PAD.

    Results
    A total of 894 incident cases of PAD were identified during an average 8.2 years of follow-up, resulting in a crude incidence rate of 3.53 per 1000 person-years. Both FPG-CV and HbA1c were significantly associated with PAD after multivariate adjustment, with corresponding hazard ratios of 1.24 [95% confidence interval (CI) 1.04–1.47] for FPG-CV in the third tertile and 1.50 (95% CI 1.10–2.04) for HbA1c ≥ 10%. The findings of the sensitivity analysis remained consistent after excluding potential confounders, demonstrating the consistency of the results.

    Conclusions
    The associations between HbA1c, variability in FPG-CV, and PAD suggest a linked pathophysiological mechanism, suggesting the crucial role of glycemic variability in clinical management and therapeutic goals in preventing PAD in type 2 diabetes.
    Relation: Cardiovascular Diabetology
    Appears in Collections:[健康產業管理學系] 期刊論文

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