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http://asiair.asia.edu.tw/ir/handle/310904400/113039
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Title: | Fasting plasma glucose variability and HbA1c are associated with peripheral artery disease risk in type 2 diabetes |
Authors: | Yan, Chun-Pai Yang, Chun-Pai Cheng-Chieh Lin, Cheng-Chieh Li, Chia-Ing Li, Chia-Ing Chiu-Shong, L Liu, Chiu-Shong Chih-Hsueh, L Lin, Chih-Hsueh Hwan, Kai-Lin Hwang, Kai-Lin Yan, Shing-Yu Yang, Shing-Yu 李采娟 Li, Tsai-Chung |
Contributors: | 醫學暨健康學院健康產業管理學系 |
Date: | 2020-01-20 |
Issue Date: | 2020-10-14 13:51:35 (UTC+8) |
Abstract: | Background
This study investigated whether visit-to-visit fasting plasma glucose (FPG) variability, as measured by the coefficient of variation (CV), increased peripheral artery disease (PAD) risk.
Methods
Individuals with type 2 diabetes from the National Diabetes Care Management Program during the period 2002–2004, ≥ 30 years of age, and free of PAD (n = 30,932) were included and monitored until 2011. Cox proportional hazards regression models were implemented to analyze related determinants of PAD.
Results
A total of 894 incident cases of PAD were identified during an average 8.2 years of follow-up, resulting in a crude incidence rate of 3.53 per 1000 person-years. Both FPG-CV and HbA1c were significantly associated with PAD after multivariate adjustment, with corresponding hazard ratios of 1.24 [95% confidence interval (CI) 1.04–1.47] for FPG-CV in the third tertile and 1.50 (95% CI 1.10–2.04) for HbA1c ≥ 10%. The findings of the sensitivity analysis remained consistent after excluding potential confounders, demonstrating the consistency of the results.
Conclusions
The associations between HbA1c, variability in FPG-CV, and PAD suggest a linked pathophysiological mechanism, suggesting the crucial role of glycemic variability in clinical management and therapeutic goals in preventing PAD in type 2 diabetes. |
Relation: | Cardiovascular Diabetology |
Appears in Collections: | [健康產業管理學系] 期刊論文
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