Fasting plasma glucose variability and HbA1c are associated with peripheral artery disease risk in type 2 diabetes

ASIA unversity > 醫學暨健康學院 > 健康產業管理學系 > 期刊論文 > Item 310904400/113039

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/113039

Title:	Fasting plasma glucose variability and HbA1c are associated with peripheral artery disease risk in type 2 diabetes
Authors:	Yan, Chun-Pai Yang, Chun-Pai Cheng-Chieh Lin, Cheng-Chieh Li, Chia-Ing Li, Chia-Ing Chiu-Shong, L Liu, Chiu-Shong Chih-Hsueh, L Lin, Chih-Hsueh Hwan, Kai-Lin Hwang, Kai-Lin Yan, Shing-Yu Yang, Shing-Yu 李采娟 Li, Tsai-Chung
Contributors:	醫學暨健康學院健康產業管理學系
Date:	2020-01-20
Issue Date:	2020-10-14 13:51:35 (UTC+8)
Abstract:	Background This study investigated whether visit-to-visit fasting plasma glucose (FPG) variability, as measured by the coefficient of variation (CV), increased peripheral artery disease (PAD) risk. Methods Individuals with type 2 diabetes from the National Diabetes Care Management Program during the period 2002–2004, ≥ 30 years of age, and free of PAD (n = 30,932) were included and monitored until 2011. Cox proportional hazards regression models were implemented to analyze related determinants of PAD. Results A total of 894 incident cases of PAD were identified during an average 8.2 years of follow-up, resulting in a crude incidence rate of 3.53 per 1000 person-years. Both FPG-CV and HbA1c were significantly associated with PAD after multivariate adjustment, with corresponding hazard ratios of 1.24 [95% confidence interval (CI) 1.04–1.47] for FPG-CV in the third tertile and 1.50 (95% CI 1.10–2.04) for HbA1c ≥ 10%. The findings of the sensitivity analysis remained consistent after excluding potential confounders, demonstrating the consistency of the results. Conclusions The associations between HbA1c, variability in FPG-CV, and PAD suggest a linked pathophysiological mechanism, suggesting the crucial role of glycemic variability in clinical management and therapeutic goals in preventing PAD in type 2 diabetes.
Relation:	Cardiovascular Diabetology
Appears in Collections:	[健康產業管理學系] 期刊論文

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