English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90451/105768 (86%)
Visitors : 11150689      Online Users : 545
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/1219


    Title: 白細胞間素4,白細胞間素6,白細胞間素10之基因多形體與急性和慢性兒童特發性血小板缺乏性紫斑症關聯性之研究
    Interleukin 4 Interleukin 6 and Interleukin 10 Polymorphisms in hildren with Acute and Chronic Immune Thrombocytopenic Purpura
    Authors: 彭慶添
    Contributors: 健康產業管理學系健康管理組在職專班
    Date: 2005
    Issue Date: 2009-10-12 18:16:34 (UTC+8)
    Publisher: 亞洲大學
    Abstract: 細胞素(cytokines)在兒童特性發紫斑症有重要的角色,我們在50位急性兒童特性發紫斑症兒童,30位慢性特性發紫斑症和100位健康兒童,以分子醫學單核苷多形體基因(SNP)的方法,做白細胞間素IL-4 intron3,白細胞間素IL-6(-572G/C),白細胞間素IL-10(-627C/A)的基因多形體(polymorphism)研究分析,結果發現在慢性特性發紫斑症和健康兒童中,IL-4 intron3的RP1/RP2基因型(genotype)的比例上有顯著的差異性 (13.3% versus 33.0%, p=0.04, odds ratio= 0.3, 95% CI=0.1-1.0),在 RP2對偶基因的頻率(allelic frequency)也有顯著的差異性 (6.7% versus 19.5%, p=0.03, odds ratio= 1.8, 95% CI=1.1-3.2); 且IL-10(-627C/A)的A/C基因型比例亦有顯著的差異性 (13.3% versus 44.0%, p=0.01, odds ratio= 0.2, 95% CI=0.1-0.7),但在急性特性發紫斑症和健康兒童中,IL-4 intron 3,IL-6(-572G/C),IL-10(-627C/A)的基因多形體無顯著的差異性。這研究發現白細胞間素IL-4 intron 3和IL-10(-627C/A)的基因多形體在兒童慢性特性發紫斑症的病理機轉有重要的相關和影響。
    Appears in Collections:[健康管理組] 博碩士論文

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML314View/Open
    1219.doc27KbMicrosoft Word193View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback