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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16069


    Title: Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis
    Authors: 黃元勵;Huang, Yuan-Li
    Contributors: 生物科技學系
    Keywords: Testosterone;Mouse;Leydig cell;Steroidogenesis;Cordyceps sinensis
    Date: 2003
    Issue Date: 2012-11-23 17:08:11 (UTC+8)
    Abstract: We demonstrate the mechanism by which Cordyceps sinensis (CS) mycelium regulates Leydig cell steroidogenesis. Mouse Leydig cells were treated with forskolin, H89, phorbol 12-myristate 13-acetate, staurosporine, or steroidogenic enzyme precursors with or without 3 mg/ml CS; then testosterone production was determined. H89, but not phorbol 12-myristate 13-acetate or staurosporine, decreased CS-treated Leydig cell steroidogenesis. CS inhibited Leydig cell steroidogenesis by suppressing the activity of P450scc enzyme, but not 3β-hydroxysteroid dehydrogenase, 17α-hydroxylase, 20α-hydroxylase, or 17β-hydroxysteroid dehydrogenase enzymes. Thus, CS activated the cAMP–protein kinase A signal pathway, but not protein kinase C, and attenuated P45scc enzyme activity to reduce human chorionic gonadotropin-stimulated steroidogenesis in purified mouse Leydig cells.
    Relation: FEBS LETTERS
    Appears in Collections:[生物科技學系] 期刊論文

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