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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16114


    Title: Beneficial Effects of Taurine on Cardiac Abnormality in NZB/W F1 Mice Fed with a High-Cholesterol Diet
    Authors: 黃志揚;HUANG, CHIH-YANG;Hsu, Tsai-Ching;Kuo, Wu-Hsien;Wu, Shih-Ping;Lin, Yueh-Min;Yen, Chun-Yu;Wu, Jen-Huang;Tzang, Bor-Show
    Contributors: 生物科技學系
    Keywords: Systemic lupus erythematosus (SLE);taurine;cardiovascular disease (CVD);NZB/W F1
    Date: 2009
    Issue Date: 2012-11-23 17:08:43 (UTC+8)
    Abstract: "A significantly higher prevalence of cardiovascular disease (CVD) is reported in patients with systemic
    lupus erythematosus (SLE) as compared with the general population and accounts for approximately
    30% of deaths in SLE patients. However, the mechanism of and treatments for CVD in patients with
    SLE are still unclear. To explore the effects of taurine on cardiac abnormality in SLE, NZB/W F1 mice
    were used as the experimental model by receiving control, cholesterol, or cholesterol/taurine diets,
    respectively. Improved cardiac histopathological changes were observed in left ventricle tissues from
    the cholesterol/taurine group as compared to the control or cholesterol group. Significant reductions of
    TUNEL-positive cells, Fas death receptor-related components, mitochondrial-dependent apoptosis,
    cardiac fibrosis, and fibrotic signaling components were detected in the left ventricle tissues from the
    cholesterol/taurine group as compared to the control or cholesterol group. Additionally, cardiac IGR1R
    survival signaling components were significantly increased in the left ventricle tissues from the
    cholesterol/taurine group as compared to the control or cholesterol group. These findings revealed
    the protective effects of taurine against the cardiac abnormalities in NZB/W F1 mice and may suggest
    the potential for clinical application of taurine in treatment of CVD in SLE."
    Relation: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
    Appears in Collections:[生物科技學系] 期刊論文

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