Proliferative Effects of Chishao on Schwann Cells are FGF-uPA, and ERK- and JNK-Dependent

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Title:	Proliferative Effects of Chishao on Schwann Cells are FGF-uPA, and ERK- and JNK-Dependent
Authors:	Huang, Kun Shan;Lu, Min-Jin;Chen, Yueh-Sheng;Tsai, Fuu-Jen;Kuo, Wei-Wen;Cheng, Yi-Chang;Lin, Chien-Chung;Tsai, Chang-Hai;黃志揚;HUANG, CHIH-YANG;Lin, Jaung-Geng;Ou, Hsiu-Chung
Contributors:	生物科技學系
Keywords:	Chishao;Proliferative Effect;Schwann Cells;Nerve Regeneration
Date:	2009
Issue Date:	2012-11-23 17:08:56 (UTC+8)
Abstract:	"This study evaluated the proliferative effects of chishao on RSC96, Schwann cells. A dose-dependent proliferative effect of chishao was obtained by methylthiazol tetrazolium (MTT), proliferating cell nuclear antigen (PCNA) Western blotting, and wound healing assays in Schwann cells administered with chishao (0–500 mg/ml), except at 500 mg/ml concentration. The chishao-treated cells also showed a dose-dependent activated fibroblast growth factor-2 (FGF-2) signaling with increased urokinase plasminogen activator (uPA) and decreased plasminogen activator inhibitor-1 (PAI-1), enhanced proliferative proteins, extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinase (JNK)-signaling. Using mitogen-actvated protein kinase (MAPK)-signaling chemical inhibitors, U0126, SB203580, and SP600125, the proliferative effects of chishao on RSC cells were identified to be ERK- and JNK- signaling dependent. Based on the results, applying appropriate doses of chishao to Schwann cells would be a potential approach for enhancing neuron regeneration.[ABSTRACT FROM AUTHOR] Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.Copyright applies to all Abstracts."
Relation:	AMERICAN JOURNAL OF CHINESE MEDICINE
Appears in Collections:	[生物科技學系] 期刊論文

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