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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16131

    Title: Protective Effects of L-Arginine Supplementation Against Exhaustive Exercise-Induced Oxidative Stress in Young Rat Tissue
    Authors: Huang, Chi-Chang;Lin, Tien-Jen;Lu, Yi-Fa;Chen, Chun-Chieh;黃志揚;HUANG, CHIH-YANG;Lin, Wan-Teng
    Contributors: 生物科技學系
    Keywords: "L-arginine;exhaustive exercise;oxidative stress;xanthine oxidase;myeloperoxidase;mitochondrial DNA deletion"
    Date: 2009
    Issue Date: 2012-11-23 17:08:57 (UTC+8)
    Abstract: "Recently, we showed that L-arginine (L-Arg) supplementation could attenuate acute exerciseinduced oxidative and inflammatory stress in aging rats. In this study, we investigate whether L-Arg
    supplementation protects cellular oxidative stress, inflammation, or the mitochondrial DNA 4834-bp
    large deletion (mtDNA4834 deletion) in 14-week-old young rats tissues during exhaustive exercise. Rats
    were randomly divided into four groups: sedentary control (SC); SC with L-Arg treatment (SC+Arg);
    exhaustive exercise (E); and exhaustive exercise with L-Arg treatment (E+Arg). Rats in the SC+Arg and
    E+Arg groups received supplemental 2% L-Arg diet. Rats in groups E and E+Arg performed an
    exhaustive running test on a treadmill. The results showed a significant increase in xanthine oxidase
    (XO) and myeloperoxidase (MPO) activities and lipid peroxide (malondialdehyde; MDA) levels of
    muscular, hepatic, and renal tissues in exercised rats as compared with sedentary rats. The increased
    XO, MPO, and MDA levels of these tissues significantly decreased in exercised rats supplemented with
    L-Arg. However, exhaustive exercise had no effect on mtDNA4834 deletions of muscular and hepatic
    tissues. The activities of creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), creatinine (CRE), lactate, uric acid, non-esterified fatty acid
    (NEFA), and D-3-hydroxybutyrate in the plasma significantly increased in the exercised rats compared
    with the sedentary rats, while the CK, lactate and uric acid levels in the plasma significantly decreased
    in L-Arg-supplemented exercised rats. These findings suggest that L-Arg supplementation reduces the
    oxidative damage to and inflammatory response in skeletal muscles, the liver, and kidneys caused by
    exhaustive exercise in young rats."
    Appears in Collections:[生物科技學系] 期刊論文

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