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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16134


    Title: Study of AMP-activated Protein Kinase Agonists by Structure-based Drug Designing
    Authors: 蔡輔仁;Tsai, Fuu-Jen;蔡長海;陳語謙;Chen, Calvin Yu-chian
    Contributors: 生物科技學系
    Keywords: Activated Protein Kinase (AMP);Docking;Molecular Simulation;QSAR
    Date: 2009
    Issue Date: 2012-11-23 17:08:59 (UTC+8)
    Abstract: AMP-activated protein kinase (AMPK) is a metabolite- sensed protein kinase in various eukaryotes. The activated AMPK regulates important proteins which cause diabetes, obesity, metabolic aberrant, and also breast cancer. In this study, the yeast AMPK structure was used as a template to model the human AMPK structure. By homology modeling, the reliable AMPK structure was built, and the active binding site was defined corresponding to X-ray crystal structure of yeast AMPK By virtual screening the database., All the potent ligands had the H-bond interaction in the key residues, same as the control. Thus, we suggested the phenylamide derivates might be the potent AMPK agonists.
    Relation: Advanced Materials Research,79-82,2187-2190.
    Appears in Collections:[生物科技學系] 期刊論文

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