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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16142

    Title: A novel strategy for designing dual-target inhibitors of KU86 and XRCC4
    Authors: 蔡輔仁;Tsai, Fuu-Jen;蔡長海;陳語謙;Chen, Calvin Yu-Chian
    Contributors: 生物科技學系
    Keywords: "KU86;XRCC4;DNA double-strain breaks (DSBs);non-homologous end joining (NHEJ)"
    Date: 2010
    Issue Date: 2012-11-23 17:09:06 (UTC+8)
    Abstract: "This is the first time that we reported about dual target
    inhibitors of KU86 and XRCC4. XRCC4 was well known as the
    downstream of KU86-DNA complex. They both play an
    important role in the DNA double-strain breaks (DSBs) repair
    system subpathway, non-homologous end joining (NHEJ).In this
    study, The protocol of docking analysis was applied to find the
    specific compounds, which had highest affinities to KU86 and
    XRCC4, from our database. The docking results were analyzed
    by cross validation. From the results above, myricetin and
    xanthone series had quietly the same core structure. The
    different shapes of binding sites from the two proteins might be
    the major factor to different affinities from these three potent
    dual-target inhibitors. Our work provides a new strategy for
    developing dual-target anticancer drug, and may contribute to
    clinical anticancer drug discovery and application. "
    Relation: IEEE/ACM Transactions on Computational Biology and Bioinformatics
    Appears in Collections:[生物科技學系] 期刊論文

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