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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16152


    Title: CYR61 regulates BMP-2-dependent osteoblast differentiation through {alpha}v{beta}3 integrin/ILK/ERK pathway
    Authors: 蘇振良;Su, Jen-Liang;邱勤;Chiou, Jean;湯智昕;Tang, Chih-Hsin;趙明;Zhao, Ming;蔡俊顥;Tsai, Chun-Hao;陳百昇;Chen, Pai-Sheng;張薏雯;Chang, Yi-Wen;簡明賢;Chien, Ming-Shien;彭竺英;Peng, Chu-Ying;蕭宏昇;Hsiao, Michael;郭明良;Kuo, Ming-Liang;嚴孟祿;Yen, Men-Luh
    Contributors: 生物科技學系
    Keywords: Bone Morphogenetic Protein (BMP);Cytokine;Differentiation;ERK;Integrin;Cysteine-rich Protein 61 (CYR61);Osteogenesis
    Date: 2010
    Issue Date: 2012-11-23 17:09:14 (UTC+8)
    Abstract: Osteoporosis is one of the most common bone pathologies. A number of novel molecules have been reported to increase bone formation including cysteine-rich protein 61 (CYR61), a ligand of integrin receptor, but mechanisms remain unclear. It is known that bone morphogenetic proteins (BMPs), especially BMP-2, are crucial regulators of osteogenesis. However, the interaction between CYR61 and BMP-2 is unclear. We found that CYR61 significantly increases proliferation and osteoblastic differentiation in MC3T3-E1 osteoblasts and primary cultured osteoblasts. CYR61 enhances mRNA and protein expression of BMP-2 in a time- and dose-dependent manner. Moreover, CYR61-mediated proliferation and osteoblastic differentiation are significantly decreased by knockdown of BMP-2 expression or inhibition of BMP-2 activity. In this study we found integrin αvβ3 is critical for CYR61-mediated BMP-2 expression and osteoblastic differentiation. We also found that integrin-linked kinase, which is downstream of the αvβ3 receptor, is involved in CYR61-induced BMP-2 expression and subsequent osteoblastic differentiation through an ERK-dependent pathway. Taken together, our results show that CYR61 up-regulates BMP-2 mRNA and protein expression, resulting in enhanced cell proliferation and osteoblastic differentiation through activation of the αvβ3 integrin/integrin-linked kinase/ERK signaling pathway.
    Relation: JOURNAL OF BIOLOGICAL CHEMISTRY
    Appears in Collections:[生物科技學系] 期刊論文

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