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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16163


    Title: Proliferative Effects of Chishao on Injured Peripheral Neurons
    Authors: ;Fang, Wen-Kuei;Weng, Yi-Jiun;Chang, Mu-Hsin;Lin, Chien-Chung;Chen, Yueh-Sheng;Hsu, Hsi-Hsien;Tsai, Fuu-Jen;Tsai, Chang-Hai;Kuo, Wu-Hsien;Lu, Chung Yen;黃志揚;HUANG, CHIH-YANG
    Contributors: 生物科技學系
    Keywords: Chishao;Proliferative Effect;Sciatic Nerve;Nerve Regeneration
    Date: 2010
    Issue Date: 2012-11-23 17:09:22 (UTC+8)
    Abstract: "The aim of the study was to evaluate the proliferative effects of chishao on neuron regeneration. A silicone rubber nerve guide across a 15-mm gap was filled with different concentrations of chishao (0-125 mg/ml) in the dissected sciatic nerve of the right leg in SD rats. The left legs were used as control. After eight weeks, the regenerated nerves showed dose-dependently activated fibroblast growth factor-2 (FGF-2) signaling with increased urokinase plasminogen activator (uPA), decreased plasminogen activator inhibitor-1 (PAI-1) and enhanced proliferative proteins, extracellular signal regulated kinase (ERK)- and c-Jun N-terminal kinase (JNK)-signalings. The results imply that applying an appropriate dose of chishao would be a potential approach for enhancing neuron regeneration.[ABSTRACT FROM AUTHOR]

    Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.Copyright applies to all Abstracts."
    Relation: AMERICAN JOURNAL OF CHINESE MEDICINE
    Appears in Collections:[生物科技學系] 期刊論文

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