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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16163

    Title: Proliferative Effects of Chishao on Injured Peripheral Neurons
    Authors: ;Fang, Wen-Kuei;Weng, Yi-Jiun;Chang, Mu-Hsin;Lin, Chien-Chung;Chen, Yueh-Sheng;Hsu, Hsi-Hsien;Tsai, Fuu-Jen;Tsai, Chang-Hai;Kuo, Wu-Hsien;Lu, Chung Yen;黃志揚;HUANG, CHIH-YANG
    Contributors: 生物科技學系
    Keywords: Chishao;Proliferative Effect;Sciatic Nerve;Nerve Regeneration
    Date: 2010
    Issue Date: 2012-11-23 17:09:22 (UTC+8)
    Abstract: "The aim of the study was to evaluate the proliferative effects of chishao on neuron regeneration. A silicone rubber nerve guide across a 15-mm gap was filled with different concentrations of chishao (0-125 mg/ml) in the dissected sciatic nerve of the right leg in SD rats. The left legs were used as control. After eight weeks, the regenerated nerves showed dose-dependently activated fibroblast growth factor-2 (FGF-2) signaling with increased urokinase plasminogen activator (uPA), decreased plasminogen activator inhibitor-1 (PAI-1) and enhanced proliferative proteins, extracellular signal regulated kinase (ERK)- and c-Jun N-terminal kinase (JNK)-signalings. The results imply that applying an appropriate dose of chishao would be a potential approach for enhancing neuron regeneration.[ABSTRACT FROM AUTHOR]

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    Appears in Collections:[生物科技學系] 期刊論文

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