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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16164


    Title: Protein Kinase C Alpha Location and the Expression of Phospho-MEK and MDR1 in Hepatitis Virus-Related Hepatocellular Carcinoma Biopsies
    Authors: ;Lin, Chien-Chung;Hwang, Jin-Ming;Tsai, Min-Ting;Su, Wei-Wen;Chen, Li-Mien;Lai, Tung-Yuan;Hsu, Hsi-Hsien;Yen, Shiow-Kang;黃志揚;HUANG, CHIH-YANG;Liu, Jer-Yuh
    Contributors: 生物科技學系
    Keywords: hepatitis C virus;hepatocellular carcinoma;MDR1;phospho-MEK;protein kinase C alpha
    Date: 2010
    Issue Date: 2012-11-23 17:09:23 (UTC+8)
    Abstract: "The purpose of this study was to elucidate the function of protein kinase C (PKC) α in human
    hepatocellular carcinoma (HCC). Histoimmunopathologic techniques were used to determine the
    localization and/or expression of PKCα, phospho-mitogen-acrivated protein kinase (MEK) and multidrug
    resistance 1 (MDR1) in HCC biopsies. Expression of PKCα, phospho-MEK and MDR1 was significantly
    increased in the region of HCC location compared with the non-tumor location. The HCC tissues were
    classified as cytosolic type, where PKCα was deposited in the cytoplasm in > 50% of cells, or membranous
    type for others. The results showed that the higher expression levels of phospho-MEK and MDR1 in
    HCC location were significantly associated with those patients whose cells were of the membranous type.
    Moreover, the expression of MDR1 in HCC location was also significantly associated with the phosphoMEK, and was significantly higher in the patients with anti-HCV negative readings. The results indicate
    that elevated expression of MDR1 in HCC patients with non-HCV infection may be mediated through
    PKC signaling pathway."
    Relation: CHINESE JOURNAL OF PHYSIOLOGY
    Appears in Collections:[生物科技學系] 期刊論文

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