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    题名: CCN3 increases BMP-4 expression and bone mineralization in osteoblasts
    作者: 黃元勵;Huang, Yuan-Li;Chen, YH;Tang, CH
    贡献者: 生物科技學系
    关键词: CCN3;Osteoblasts;BMP-4;ILK;p38;JNK
    日期: 2011
    上传时间: 2012-11-23 17:09:34 (UTC+8)
    摘要: "The nephroblastoma overexpressed (NOV) gene, also called CCN3, regulates
    differentiation of skeletal mesenchymal cells. Bone morphogenetic proteins (BMPs) play
    important roles in osteoblast differentiation and bone formation, but the effects of CCN3
    on BMP expression and bone formation in cultured osteoblasts are largely unknown.
    Here we found that CCN3 increased BMP-4 expression and bone nodule formation in
    cultured osteoblast. Monoclonal antibodies for  and v5 integrins, and inhibitors
    of integrin-linked kinase (ILK), p38, and JNK, all inhibited CCN3-induced bone nodule
    formation and BMP-4 up-regulation of osteoblasts. CCN3 stimulation increased the
    kinase activity of ILK and phosphorylation of p38 and JNK. Inhibitors of activator
    protein-1 (AP-1) also suppressed bone nodule formation and BMP-4 expression enhanced
    by CCN3. Moreover, CCN3-induced c-Jun translocation into the nucleus, and the binding
    of c-Jun to the AP-1 element on the BMP-4 promoter were both inhibited by specific
    inhibitors of the ILK, p38, and JNK cascades. Taken together, our results provide
    evidence that CCN3 enhances BMP-4 expression and bone nodule formation in
    osteoblasts, and that the integrin receptor, ILK, p38, JNK and AP-1 signaling pathways
    may be involved."
    显示于类别:[生物科技學系] 期刊論文


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