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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16187

    Title: Efficacy of Epigallocatechin-3-Gallate and Amla (Emblica officinalis) Extract for the Treatment of Uremic Diabetic Patients
    Authors: Tung-Sheng Chen;Show-Yih Liou;Hsi-Chin Wu;Fuu-Jen Tsai;Chang-Hai Tsai;Chih-Yang Huang;Yen-Lin Chang
    Contributors: 生物科技學系
    Date: 2011
    Issue Date: 2012-11-23 17:09:40 (UTC+8)
    Abstract: Uremic patients with diabetes suffer from high levels of oxidative stress due to regular hemodialysis therapy (neutrophil activation induced by hemo-incompatibility between the hemodialyser and blood) and complications associated with diabetes. Several plasma biomarkers were screened in 13 uremic diabetic patients after receiving the mixture of (–)-epigallocatechin gallate (EGCG), a major component of green tea extract, and Amla extract (AE), from Emblica officinalis, the Indian gooseberry, for 3 months. We found that oral administration of a 1:1 mixture of EGCG and AE for 3 months significantly improved antioxidant defense as well as diabetic and atherogenic indices in uremic patients with diabetes. Furthermore, no significant changes in hepatic function, renal function, or inflammatory responses were observed. These results suggest that a 1:1 combination of EGCG and AE is a safe and effective treatment for uremic patients with diabetes.
    Relation: JOURNAL OF MEDICINAL FOOD,14(7-8),718-723.
    Appears in Collections:[生物科技學系] 期刊論文

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