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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16197

    Title: Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA
    Authors: ;Chou, Ming-Chih;黃志揚;HUANG, CHIH-YANG;Lin, Chien-Chung
    Contributors: 生物科技學系
    Keywords: fibroblast growth-factors;schwann-cell;in-vivo;apoptosis;system;expression;ischemia;hypoxia;kinase;rats
    Date: 2011
    Issue Date: 2012-11-23 17:09:48 (UTC+8)
    Abstract: This study evaluates the proliferative effects of danshen and its monomer extract, tanshinone IIA, on Schwann cell proliferation. A piece of silicone rubber was guided across a 15-mm gap in the sciatic nerve of a rat. This nerve gap was then filled with different concentrations of danshen (0-100 mg/mL). The results showed that danshen increased the expressions of uPA, cyclin D1, E and ERK, JNK, and P38 MAP kinases via the FGF-2 signaling pathway in a dose-dependent manner. RSC96, Schwann cells were also administered with danshen (0, 20, 40, 60, 80, and 100 mu g/mL) and tanshinone IIA (0, 2, 4, 6, 8, and 10 mu g/mL). In lower concentrations, danshen and tanshinone IIA exhibited an apparent effect on Schwann cells. Similar effects were also demonstrated in the FGF-2-uPA regulating cascade and cell cycle proliferative protein results. Schwann cell migration was elevated as well. We used MAPK-signaling chemical inhibitors and identified the proliferative effects of danshen and tanshinone IIA as MAPK-signaling dependent. The results from the in vitro systems indicate that danshen and tanshinone IIA can be used to induce Schwann cell proliferation, and in vivo results potentially suggest that danshen and tanshinone IIA might enhance neuron regeneration.
    Relation: Evidence-based Complementary and Alternative Medicine
    Appears in Collections:[生物科技學系] 期刊論文

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