ASIA unversity:Item 310904400/16221
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    题名: BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment.
    作者: ;Woodward, W.A.,;Yu, D.,;Hortobagyi, G.N.;洪明奇;Hung, Mien-Chie
    贡献者: 生物科技學系
    日期: 2012
    上传时间: 2012-11-23 17:10:07 (UTC+8)
    摘要: "Breast cancer initiating cells (BCICs), which can fully recapitulate the tumor origin and are often resistant to
    chemo- and radiotherapy, are currently considered as a major obstacle for breast cancer treatment. Here, we
    show that BIKDD, a constitutively active mutant form of proapoptotic gene, BIK, effectively induces
    apoptosis of breast cancer cells and synergizes with lapatinib. Most importantly, BikDD significantly reduces
    BCICs through co-antagonism of its binding partners Bcl-2, Bcl-xL, and Mcl-1, suggesting a potential
    therapeutic strategy targeting BCICs. Furthermore, we developed a cancer-specific targeting approach for
    breast cancer that selectively expresses BikDD in breast cancer cells including BCICs, and demonstrated
    its potent antitumor activity and synergism with lapatinib in vitro and in vivo."
    显示于类别:[生物科技學系] 期刊論文


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