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    Title: Transcriptional and subcellular regulation of the TRIP-Br family
    Authors: ;2.Lai, IL;Wang, SY;姚雅莉;Yao, Ya-Li;Yang, WM
    Contributors: 生物科技學系
    Keywords: Bromodomain;PCAF;STAF65γ;KAP1
    Date: 2007-02
    Issue Date: 2012-11-23 17:10:31 (UTC+8)
    Abstract: TRIP-Brs are a recently discovered set of proteins whose functions remain poorly characterized. Here we report the identification of TRIP-Br3 as a member of the TRIP-Br family along with evidence showing that TRIP-Brs interact with bromodomain-containing transcriptional cofactors PCAF, STAF65γ, and KAP1. PCAF, a histone acetyltransferase; STAF65γ, a protein associated with histone acetylation activity; and KAP1, a corepressor, influence the transcriptional activity of TRIP-Brs differentially. Finally, while all three TRIP-Brs are localized to the nucleus, TRIP-Br2 and TRIP-Br3 are also present in the cytoplasm through interaction with CRM1. Our results suggest that different TRIP-Brs function by interacting with a wide variety of bromodomain-containing transcriptional regulators in different subcellular locales.
    Relation: GENE,388(1-2),102–109.
    Appears in Collections:[Department of Biotechnology] Journal Article

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